Triamcinolone

Names and Identifiers

IUPAC name

(1R,2S,10S,11S,13R,14S,15S,17S)-1-fluoro-13,14,17-trihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-one

IUPAC Traditional name

triamcinolone

Synonyms

TriamcinoloneFluoxyprednisoloneFluoxiprednisoloneTriamcinolonum [INN]Triamcinolone hexacetonideTiamcinolonum [INN-Latin]TriamcinaloneTriamcinolone acetonideTriamcinolone diacetateTriamcinolona [INN-Spanish]

Brand Name

KenalogAdcortylAristocortAristocort AAristogelDelphicortFlutexOrionSk-TriamcinoloneTriamcetTriatexTristojectAristospanCinolone-TNasacortNasacort HfaOmcilonOraloneTriamcinolonTridermAristocort TabletsKenalog-40LedercortNasacort AqRodinoloneTriacortTriam-TablinenCelesteCinoloneKenacortKenacort-AKenacort-AgTriamcinlonVetalogVolonTriloneAzmacortKenalog-10OmicilonPolcortolonTriacetVolon AFougeraKenalog in OrabaseKenalog-HOracortTri-NasalTricortaleTrymex

Registration numbers

PubChem CID

31307

PubChem SID

46507950

CAS Number

124-94-7

Properties

Physical Property

Hydrophobicity(logP)

0.2

Solubility

80 mg/L

Molecule Details

Drug Groups

approved

Description

A glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. (From Martindale, The Extra Pharmacopoeia, 30th ed, p739)

Indication

For the treatment of perennial and seasonal allergic rhinitis.

Pharmacology

Triamcinolone and its derivatives are synthetic glucocorticoids that are used for their antiinflammatory or immunosuppressive properties.

Toxicity

LD₅₀=>500mg/kg (in rats)

Affected Organisms

Humans and other mammals

Biotransformation

Hepatic.

Absorption

Rapid absorption following oral administration