Substance
ID:470
Names and Identifiers
Brand Name
Cinalukast [Usan:Inn]
IUPAC name
3-({3-[(E)-2-(4-cyclobutyl-1,3-thiazol-2-yl)ethenyl]phenyl}carbamoyl)-2,2-diethylpropanoic acid
Synonyms
Cinalukast
IUPAC Traditional name
@cinalukast
Properties
Physical Property
Hydrophobicity(logP)
4
Molecule Details
Drug Groups
approved
Description
Used in the treatment of asthma, cinalukast selectively antagonizes leukotriene D4 (LTD4) at the cysteinyl leukotriene receptor, CysLT1, in the human airway. Cinalukast inhibits the actions of LTD4 at the CysLT1 receptor, preventing airway edema, smooth muscle contraction, and enhanced secretion of thick, viscous mucus.
Indication
For Protection against second- phase inflamation in exercise-induced bronchoconstriction and Asthma.
Pharmacology
Used in the treatment of asthma, cinalukast selectively antagonizes leukotriene D4 (LTD4) at the cysteinyl leukotriene receptor, CysLT1, in the human airway. Cinalukast inhibits the actions of LTD4 at the CysLT1 receptor, preventing airway edema, smooth muscle contraction, and enhanced secretion of thick, viscous mucus.
Affected Organisms
Humans and other mammals
Molecular Spectra
No Data Available
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References
No Data Available
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