Substance

ID:4607

Names and Identifiers
Brand Name
DrotinNo-Spa
Synonyms
Drotaverinedrotaverin
IUPAC name
(1Z)-1-[(3,4-diethoxyphenyl)methylidene]-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline
IUPAC Traditional name
drotaverine
Registration numbers
PubChem CID
1712095
CAS Number
985-12-6
PubChem SID
99443287
Properties
No Data Available
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Molecule Details
Drug Groups
approved
Description
Drotaverine (INN, also known as drotaverin) is an antispasmodic drug, structurally related to papaverine. Drotaverine is a selective inhibitor of phosphodiesterase 4, and has no anticholinergic effects. Drotaverine has been shown to possess dose-dependant analgesic effects in animal models. One small study has shown drotaverine to be eliminated mainly non-renally.
Indication
Used in the treatment of functional bowel disorders and alleviating pain in renal colic.
Pharmacology
Drotaverine is a spasmolytic agent by inhibiting PDE4 in smooth muscle cells.
Affected Organisms
Humans and other mammals
Biotransformation
Hepatic
Absorption
Bioavailability is highly variable
Half Life
7 to 12 hours
Protein Binding
80 to 95%
References
• Bolaji OO, Onyeji CO, Ogundaini AO, Olugbade TA, Ogunbona FA: Pharmacokinetics and bioavailability of drotaverine in humans. Eur J Drug Metab Pharmacokinet. 1996 Jul-Sep;21(3):217-21. [Pubmed]
External Links
• [Wikipedia]
Molecular Spectra
No Data Available
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References
• Bolaji OO, Onyeji CO, Ogundaini AO, Olugbade TA, Ogunbona FA: Pharmacokinetics and bioavailability of drotaverine in humans. Eur J Drug Metab Pharmacokinet. 1996 Jul-Sep;21(3):217-21. Pubmed
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