Substance
ID:4598
Names and Identifiers
Synonyms
{3-Phenyl-1H-naphtho[2,} 1-b\]pyran-1-onebeta-Naphthoflavone3-phenyl-1H-benzo[f]chromen-1-one (ACD/Name 4.0)5,6 BenzoflavoneBNFN3633_SIGMAWLN: T B666 CV FOJ ER{1H-Naphtho[2,} 1-b\]pyran-1-one, 3-phenyl-beta-NF1H-Naphtho(2,1-b)pyran-1-one, 3-phenyl-1H-Naphtho[2,1-b]pyran-1-one, 3-phenyl-BIDD:ER05703-Phenyl-1H-benzo[f]chromen-1-one3-Phenyl-benzo[f]chromen-1-one5,6-benzoflavone3-Phenyl-1H-naphtho[2,1-b]pyran-1-one3-Phenyl-1H-naphtho(2,1-b)pyran-1-one
IUPAC Traditional name
β-naphthoflavone
IUPAC name
3-phenyl-1H-benzo[f]chromen-1-one
Properties
No Data Available
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Molecule Details
Drug Groups
experimental
Description
beta-Naphthoflavone, also known as 5,6-benzoflavone, is a potent agonist of the aryl hydrocarbon receptor and as such is an inducer of such detoxification enzymes as cytochromes P450 (CYPs) and uridine 5'-diphospho-glucuronosyltransferases (UGTs). β-Naphthoflavone is a putative chemopreventive agent.
References
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Chlouchi A, Girard C, Bonet A, Viollon-Abadie C, Heyd B, Mantion G, Martin H, Richert L: Effect of chrysin and natural coumarins on UGT1A1 and 1A6 activities in rat and human hepatocytes in primary culture. Planta Med. 2007 Jul;73(8):742-7. Epub 2007 Jun 28.
[Pubmed]
•
Izzotti A, Bagnasco M, Cartiglia C, Longobardi M, Camoirano A, Tampa E, Lubet RA, De Flora S: Modulation of multigene expression and proteome profiles by chemopreventive agents. Mutat Res. 2005 Dec 11;591(1-2):212-23. Epub 2005 Aug 3.
[Pubmed]
External Links
Molecular Spectra
No Data Available
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References
• Izzotti A, Bagnasco M, Cartiglia C, Longobardi M, Camoirano A, Tampa E, Lubet RA, De Flora S: Modulation of multigene expression and proteome profiles by chemopreventive agents. Mutat Res. 2005 Dec 11;591(1-2):212-23. Epub 2005 Aug 3. Pubmed
• Chlouchi A, Girard C, Bonet A, Viollon-Abadie C, Heyd B, Mantion G, Martin H, Richert L: Effect of chrysin and natural coumarins on UGT1A1 and 1A6 activities in rat and human hepatocytes in primary culture. Planta Med. 2007 Jul;73(8):742-7. Epub 2007 Jun 28. Pubmed