Substance
ID:4546
Names and Identifiers
Synonyms
3-isobutyryl-2-isopropylpyrazolo(1,5-a)pyridineIbudilastumKetasUNII-M0TTH61XC5Pyrazolo(1,5-a)pyridine, 3-isobutyryl-2-isopropyl-MN-166EyevinalIbudilastAV-411Tocris-16943-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridineIbudilast (jan/inn)Ibudilast [inn:jan]Ke tasLopac-I-01572-Isopropyl-3-isobutyrylpyrazolo(1,5-a)pyridineI0157_SIGMAIbudilastum [latin]Ketas (TN)
IUPAC Traditional name
ketas
IUPAC name
2-methyl-1-[2-(propan-2-yl)pyrazolo[1,5-a]pyridin-3-yl]propan-1-one
Properties
No Data Available
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Molecule Details
Drug Groups
approved; investigational
Description
Ibudilast is an anti-inflammatory and neuroprotective oral agent which shows an excellent safety profile at 60 mg/day and provides significantly prolonged time-to-first relapse and attenuated brain volume shrinkage in patients with relapsing-remitting (RR) and/or secondary progressive (SP) multiple sclerosis (MS). Ibudilast is currently in development in the U.S. (codes: AV-411 or MN-166), but is approved for use as an antiinflammatory in Japan.
Indication
For the treatment of multiple sclerosis, asthma, and cerebrovascular disease.
Toxicity
Neuroprotective role of phosphodiesterase inhibitor ibudilast on neuronal cell death induced by activated microglia
Affected Organisms
Humans and other mammals
Half Life
19 hours
External Links
Molecular Spectra
No Data Available
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References
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