Substance
ID:4520
Names and Identifiers
Brand Name
FluvertSibeliumIssiumVertixFlufenalApo-flunarizine capsulesNovo-FlunarizineZinasen
IUPAC name
1-[bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine
Synonyms
Flunarizinum [inn-latin](E)-1-[Bis-(p-fluorophenyl)methyl]-4-cinnamylpiperazineFlunarizine HydrochlorideFlunarizina [inn-spanish]1-(Bis(4-fluorophenyl)methyl)-4-cinnamylpiperazineflunarizine dihydrochlorideFlunarizine
IUPAC Traditional name
flunarizine
Properties
No Data Available
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Molecule Details
Drug Groups
approved
Description
Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy.
Indication
Used in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy.
Pharmacology
Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity.
Affected Organisms
Humans and other mammals
Biotransformation
Hepatic, to two metabolites via N-dealylation and hydroxylation.
Absorption
85% following oral administration.
Half Life
18 days
Protein Binding
99% bound to plasma proteins
External Links
Molecular Spectra
No Data Available
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References
No Data Available
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