Substance
ID:4512
Names and Identifiers
Synonyms
2-Methyl-3-o-tolyl-4(3H)-quinazolinoneMAOAMetachalon [czech]Methaqualonum [inn-latin]Methylquinazolone hydrochlorideMTQ2-Methyl-3-(o-tolyl)-4-quinazolone hydrochloride2-Methyl-3-(2-tolyl)quinazol-4-one2-Methyl-3-(2-methylphenyl)-4-quinazolinone3,4-Dihydro-2-methyl-4-oxo-3-o-tolylquinazolineDiamthazole dihydrochlorideMTQ hydrochloride2-Methyl-3-o-tolyl-4(3H)-chinazolinon [German]2-Methyl-3-o-tolyl-3H-quinazolin-4-one2-Methyl-3-(o-tolyl)-4(3H)-quinazolinone hydrochloride2-Methyl-3-(2-methylphenyl)-4(3H)-quinazolinone2-Methyl-3-tolyl-4-oxybensdiazine2-Methyl-3-o-tolyl-4(3H)-chinazolone2-Methyl-3-o-tolyl-4 (3H)-chinazolinon2-Methyl-3-tolylchinazolon-4 hydrochloride2-Methyl-3-o-tolyl-4-quinazoloneMetaqualone [dcit]Methyl-o-tolylquinazoloneMethaqualoneMethaqualone hydrochloride2-Methyl-3-(o-tolyl)-3,4-dihydro-4-quinazolinoneMetacualona [inn-spanish]
Brand Name
SoverinTR 495 monohydrochlorideParminalQuaaludeSomnafacSomnofacSoporSopor hydrochlorideMelsedinMequalMethasedOmnylOrtonalParestDormigoa-schlafmittelHyptorHyptor baseOrthonalRorer 148RouloneSomnomedTorinalTuazoleIpnofilMelsedMetakvalonMozambinNoctileneOptinoxanCitexalDormogenDorsedinFadormirHyminal monohydrochlorideHypcolQuaalude hydrochlorideRevonalSomberolSonalTuazoloneMollinoxNethaqualoneNobedormNormi-noxOptimilQZ 2 hydrochlorideMelsed HCLMelsominMetaqualonMethachalonumMethaqualonMetolquizoloneAqualCateudylDormigoaHolodormHyminalRorer 714RouqualoneSindesvelTuazolDormutilHypocolMequinMethaqualoneinoneMotolonPro-dorm
IUPAC Traditional name
methaqualone
IUPAC name
2-methyl-3-(2-methylphenyl)-3,4-dihydroquinazolin-4-one
Properties
No Data Available
Click here to submit data
Molecule Details
Drug Groups
illicit; withdrawn
Description
Methaqualone is a sedative-hypnotic drug that is similar in effect to barbiturates, a general central nervous system depressant. The sedative-hypnotic activity was first noted by Indian researchers in the 1950s and in 1962 methaqualone itself was patented in the US by Wallace and Tiernan. Its use peaked in the early 1970s as a hypnotic, for the treatment of insomnia, and as a sedative and muscle relaxant. It has also been used illegally as a recreational drug, commonly known as Quaaludes, Sopors, Ludes or Mandrax (particularly in the 1970s in North America) depending on the manufacturer. Since at least 2001, it has been widely used in South Africa, where it is commonly referred to as "smarties" or "geluk-tablette" (meaning happy tablets). Clandestinely produced methaqualone is still seized by government agencies and police forces around the world. [Wikipedia]
Indication
For the treatment of insomnia, and as a sedative and muscle relaxant.
Toxicity
Symptoms of overdose include delirium, convulsions, muscle spasms or seizure, cardiac arrest, shortness or loss of breath, vomiting or nausea, and coma or death. The LD50 for mice is 1250 mg/kg and for rats is 326 mg/kg (Strasenburg Labs).
Affected Organisms
Humans and other mammals
References
•
Potential Analgesics. Part I. Synthesis of substituted 4-quinazolones, I. K. Kacker and S. H. Zaheer, J. Ind. Chem. Soc. 28 (1951), pp. 344–346.
External Links
Molecular Spectra
No Data Available
Click here to submit data
References
• Potential Analgesics. Part I. Synthesis of substituted 4-quinazolones, I. K. Kacker and S. H. Zaheer, J. Ind. Chem. Soc. 28 (1951), pp. 344–346.