Substance
ID:449849
Names and Identifiers
IUPAC name
1-[1-(1-benzothiophen-2-yl)ethyl]-1-hydroxyurea
Synonyms
ZYFLOLeutrolZileutonZyflo CR
IUPAC Traditional name
1-[1-(1-benzothiophen-2-yl)ethyl]-1-hydroxyurea
Registration numbers
CAS Number
Properties
Product Information
Application(s)
Investigated for treatment of irritable bowel disease
Potential antiasthmatic agent
Antiallergic
Antiinflammatory agent
Pharmacology Properties
Mechanism of Action
5-Lipoxygenase (5-LOX) inhibitor
inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation
weak inhibitor of CYP 1A2
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• 1. Malo PE, Bell RL, Shaughnessy TK, Summers JB, Brooks DW, Carter GW. The 5-lipoxygenase inhibitory activity of zileuton in in vitro and in vivo models of antigen-induced airway anaphylaxis.
• 2. Lu P, Schrag ML, Slaughter DE, Raab CE, Shou M, Rodrigues AD. Mechanism-based inhibition of human liver microsomal cytochrome P450 1A2 by zileuton, a 5-lipoxygenase inhibitor.
• Drug Metab Dispos. 2003 Nov;31(11):1352-60.
• Pulm Pharmacol. 1994 Apr;7(2):73-9