Substance
ID:449834
Names and Identifiers
IUPAC name
methyl (1S,4aS,7aS)-7-(hydroxymethyl)-1-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1H,4aH,5H,7aH-cyclopenta[c]pyran-4-carboxylate
Synonyms
GeniposideGenipin 1-glucosideJasminoidin
IUPAC Traditional name
methyl (1S,4aS,7aS)-7-(hydroxymethyl)-1-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1H,4aH,5H,7aH-cyclopenta[c]pyran-4-carboxylate
Registration numbers
CAS Number
Properties
Product Information
Application(s)
Anti-angiogenic
Neuroprotective
Antitumor
Anti-inflammatory
Antithrombotic
Biological Source
Constit. of Gardenia jasminoides
Pharmacology Properties
Mechanism of Action
Glucagon-like peptide-1 (GLP-1) receptor agonist
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• Cancer Lett. 113 (1997), pp. 31?7.
• 5. Lee P, Lee J, Choi SY, Lee SE, Lee S, Son D. Geniposide from Gardenia jasminoides attenuates neuronal cell death in oxygen and glucose deprivation-exposed rat hippocampal slice culture.
• 3. Koo HJ, Lim KH, Jung HJ, Park EH. Anti-inflammatory evaluation of gardenia extract, geniposide and genipin. J Ethnopharmacol. 2006 Feb 20;103(3):496-500. Epub 2005 Sep 19.
• 1. Hsua HY, Yangb JJ, Lina SY, Lin CC. Comparisons of geniposidic acid and previous termgeniposidenext term on antitumor and radioprotection after sublethal irradiation,
• 2. Koo HJ, Lee S, Shin KH, Kim BC, Lim CJ, Park EH. Geniposide, an anti-angiogenic compound from the fruits of Gardenia jasminoides. Planta Med. 2004 May;70(5):467-9.
• 4. Suzuki Y, Kondo K, Ikeda Y, Umemura K. Antithrombotic effect of geniposide and genipin in the mouse thrombosis model. Planta Med. 2001 Dec;67(9):807-10.
• 6. Liu J, Yin F, Zheng X, Jing J, Hu Y. Geniposide, a novel agonist for GLP-1 receptor, prevents PC12 cells from oxidative damage via MAP kinase pathway.
• Neurochem Int. 2007 Nov-Dec;51(6-7):361-9. Epub 2007 May 6.
• Biol Pharm Bull. 2006 Jan;29(1):174-6.