Substance

ID:449832

Names and Identifiers
IUPAC Traditional name
4-[(5R)-12,12-dimethyl-3,11-dioxatricyclo[8.4.0.02,7]tetradeca-1,7,9,13-tetraen-5-yl]benzene-1,3-diol
IUPAC name
4-[(5R)-12,12-dimethyl-3,11-dioxatricyclo[8.4.0.02,7]tetradeca-1,7,9,13-tetraen-5-yl]benzene-1,3-diol
Synonyms
Glabridin4-[3,4-Dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-3-yl]-1,3-benzenediol
Registration numbers
CAS Number
59870-68-7
Properties
Product Information
Application(s)
Antimicrobial
Anti-proliferative
Cytotoxic
Estrogenic
Anti-inflammatory
Biological Source
Isol. from Glycyrrhiza glabra
Pharmacology Properties
Mechanism of Action
Tyrosinase inhibitor
Human cytochrome P450S 3A4, 2B6, 2C9 inhibitor
Melanogenesis inhibitor
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• 1. T. Fukai, H. Sakagami, M. Toguchi, F. Takayama, I. Iwakura and T. Atsumi, Cytotoxic activity of low molecular weight polyphenols against human oral tumor cell lines,
• 7. Choi, E. The licorice root derived isoflavan glabridin increases the function of osteoblastic
• Drug Metab Dispos 30 (2002), pp. 709?15.
• 5. O. Nerya, J. Vaya, R. Musa, S. Izrael, R. Ben-Arie and S. Tamir, Glabrene and isoliquiritigenin as tyrosinase inhibitors from licorice roots, J Agric Food Chem 51 (2003), pp. 1201?207.
• 2. T. Fukai, A. Marumo, K. Kaitou, T. Kanda, S. Terada and T. Nomura, Anti-Helicobacter pylori flavonoids from licorice extract, Life Sci 71 (2002), pp. 1449?463
• 4. T. Yokota, H. Nishio, Y. Kubota and M. Mizoguchi, The inhibitory effect of glabridin from licorice extracts on melanogenesis and inflammation, Pigment Cell Res 11 (1998), pp. 355?61.
• Anticancer Res 20 (2000), pp. 2525?536.
• 3. S. Tamir, M. Eizenberg, D. Somjen, S. Izrael and J. Vaya, Estrogen-like activity of glabrene and other constituents isolated from licorice root, J Steroid Biochem Mol Biol 78 (2001), pp. 291?98.
• 6. U.M. Kent, M. Aviram, M. Rosenblat and P.F. Hollenberg, The licorice root derived isoflavan glabridin inhibits the activities of human cytochrome P450S 3A4, 2B6, and 2C9,
• MC3T3-E1 cells. Biochem. Pharm. 2005, 70, 363-368.
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