Substance

ID:449829

Names and Identifiers
IUPAC name
(10R)-10-[(5S)-6-methyl-2H,5H,6H,7H,8H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-3,5,11-trioxatricyclo[7.3.0.02,6]dodeca-1(9),2(6),7-trien-12-one
Synonyms
d-Bicuculline
IUPAC Traditional name
(10R)-10-[(5S)-6-methyl-2H,5H,6H,7H,8H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-3,5,11-trioxatricyclo[7.3.0.02,6]dodeca-1(9),2(6),7-trien-12-one
Registration numbers
CAS Number
485-49-4
Properties
Product Information
Biological Source
Alkaloid from many Corydalis spp. and several Fumaria spp. (opt. rotn. of isolates not recorded in some cases). Also isol. from Adlumia fungosa (Adlumia cirrhosa) (Fumariaceae, Papaveraceae)
Application(s)
Mimics epilepsy.
Utilised in the in vitro study of epilepsy.
Pharmacology Properties
Mechanism of Action
GABA(A)-receptor antagonist
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• 1. Manske, Can. J. Res. 7:265, 1932
• 2. Khawaled R, Bruening-Wright A, Adelman JP, Maylie J (1999) Bicuculline block of small-conductance calcium-activated potassium channels. Pflugers Arch 438: 314-321
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