Substance
ID:449825
Names and Identifiers
IUPAC name
(10S)-1,8-dihydroxy-3-(hydroxymethyl)-10-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-9,10-dihydroanthracen-9-one
Synonyms
Aloin ABarbaloin
IUPAC Traditional name
(10S)-1,8-dihydroxy-3-(hydroxymethyl)-10-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-9,10-dihydroanthracen-9-one
Registration numbers
CAS Number
Properties
Product Information
Application(s)
Laxative
Purgative
Biological Source
Constit. of various Aloe spp.
Pharmacology Properties
Mechanism of Action
Increase prostaglandin synthesis
Na+, K(+)-adenosine triphosphatase (ATPase) inhibitor
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• 1. Akao T, Che QM, Kobashi K, Hattori M, Namba T.
• 2. Ishii Y, Tanizawa H, Takino Y. Studies of aloe. III. Mechanism of cathartic effect. (2). Chem Pharm Bull (Tokyo). 1990 Jan;38(1):197-200.
• Prostaglandins. 1983 Oct;26(4):557-62.
• A purgative action of barbaloin is induced by Eubacterium sp. strain BAR, a human intestinal anaerobe, capable of transforming barbaloin to aloe-emodin anthrone. Biol Pharm Bull. 1996 Jan;19(1):136-8.
• 3. Capasso F, Mascolo N, Autore G, Duraccio MR. Effect of indomethacin on aloin and 1,8 dioxianthraquinone-induced production of prostaglandins in rat isolated colon.