Substance
ID:449817
Names and Identifiers
Synonyms
BloqueinaSvedocainBupivacaineCarbostesinNarcainMarcaineSensorcaineDuracaineMeaverin-ultra
IUPAC name
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
IUPAC Traditional name
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
Registration numbers
CAS Number
Properties
Product Information
Application(s)
Local anaesthetic
Pharmacology Properties
Mechanism of Action
presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse, and by reducing the rate of rise of the action potential
Blocks the generation and the conduction of nerve impulses,
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
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• Sorbera, L.A. et al., Drugs of the Future, 1998, 23, 838-842, (rev)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, BOO000; BOO250; BSI250; BOO500
• Wilson, T.D., Anal. Profiles Drug Subst., 1990, 19, 59, (rev)
• Csregh, I., Acta Cryst. C, 1992, 48, 1794, (cryst struct)
• Aps, C. et al., Br. J. Clin. Pharmacol., 1978, 6, 63, (pharmacol)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 1003
• Slot, H.J.B. et al., Acta Cryst. B, 1990, 46, 842, (cryst struct)
• Mangin, P. et al., J. Anal. Toxicol., 1987, 11, 27, (hplc)
• U.K. Pat., 1969, Sterling, 1 166 802; CA, 72, 43429, (synth)
• Tullar, B.F., J. Med. Chem., 1971, 14, 891, (resoln)
• Moore, D.C. et al., Acta Anaesthesiol. Scand., 1977, 21, 109, (rev)
• Jones, G.P. et al., J.C.S. Perkin 2, 1987, 415, (struct, conformn)
• Gristwood, R.W. et al., Expert Opin. Invest. Drugs, 1999, 8, 861-876, (rev)
• Foster, R.H. et al., Drugs, 2000, 59, 551-579, (rev)