Substance
ID:449807
Names and Identifiers
IUPAC name
(1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate
Synonyms
Monacolin KMevacorTancorNergadanMevinacorlovastatinLipofren
IUPAC Traditional name
(1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate
Registration numbers
CAS Number
Properties
Product Information
Biological Source
Metab. of Aspergillus terreus and Monascus ruber
Application(s)
Antihyperlipidaemic agent
Pharmacology Properties
Mechanism of Action
Inhibitor of cholesterol biosynthesis
Potent inhibitor of HMG-CoA
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• Alberts et al (1980) Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent. Proc.Natl.Acad.Sci.USA 77 3957.