Substance

ID:449799

Names and Identifiers
Synonyms
trisoralentrimethylpsoralenDermetrixLevrison4,5',8-TrimethylpsoralenTrioxysalenTripsos
IUPAC name
2,5,9-trimethyl-7H-furo[3,2-g]chromen-7-one
IUPAC Traditional name
2,5,9-trimethyl-7H-furo[3,2-g]chromen-7-one
Registration numbers
CAS Number
3902-71-4
Properties
Pharmacology Properties
Mechanism of Action
Action depends on the presence of functional melanocytes and their proliferation by photoactivated drug
Conjugates and forms covalent-bonds with DNA which leads to the formation of both monofunctional and bifunctional adducts upon photoactivation
Exact mechanism with epidermal melanocytes and keratinocytes unknown.
Product Information
Application(s)
Photosensitiser
Medicinal pigmentation agent
Radiosensitizer
Tool used in molecular biology for labelling and isolating nascent DNA fragments
Dermatological agent
Biological Source
Phytotoxic metab. of pink rot disease, produced by Sclerotinia sclerotiorum
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
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• Hassan, M.A., Anal. Profiles Drug Subst., 1981, 10, 705, (rev)
• Thompson, H.J. et al., J. Chromatogr., 1984, 314, 323, (hplc)
• IARC Monog., 1986, 40, 357; Suppl. 7, 366; Suppl. 6, 541, (rev, tox)
• Martindale, The Extra Pharmacopoeia, 31st edn., Pharmaceutical Press, 1996, 1098
• Bender, D.R. et al., J.O.C., 1979, 44, 2176, (synth)
• Nivsarkar, M. et al., Biochem. Mol. Biol. Int., 1996, 38, 625, (pharmacol)
• Russev, G. et al., J. Mol. Biol., 1982, 161, 77, (pharmacol)
• Dimitrova, D. et al., Nucleic Acids Res., 1993, 21, 5554, (pharmacol)
• Gencheva, M. et al., J. Biol. Chem., 1996, 271, 2608, (pharmacol)
• Aldrich Library of FT-IR Spectra, 1st edn., 1985, 2, 684C, (ir)
• Kaufman, K.D., J.O.C., 1961, 26, 117; 1980, 45, 738, (synth, uv)
• Caporale, G. et al., Experientia, 1967, 23, 985, (pharmacol)
• Elgamal, M.H.A. et al., Phytochemistry, 1979, 18, 139, (cmr)
• Taskineu, J. et al., Biomed. Mass Spectrom., 1980, 7, 556, (ms)
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