Substance
ID:449776
Names and Identifiers
IUPAC name
7H-furo[3,2-g]chromen-7-one
Synonyms
PsoralenFicusinFuro[4',5':6,7]coumarin
IUPAC Traditional name
7H-furo[3,2-g]chromen-7-one
Registration numbers
CAS Number
Properties
Product Information
Application(s)
This takes advantage of the high UV absorbance of psoralen
An important use of psoralen is in PUVA treatment for skin problems such as psoriasis and (to a lesser extent) eczema and vitiligo.
Biological Source
From Psoralea corylifolia, Ficus salicifolia, Heracleum leskovii, Ruta chalepensis, Dictamnus hispanicus, etc.
Found in common vegetables, e.g. parsnip, celery esp. if diseased or `spoiled'
Pharmacology Properties
Mechanism of Action
Radiosensitizer
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• Ceska, O. et al., Experientia, 1986, 42, 1302, (occur, tox)
• Zubia, E. et al., Tetrahedron, 1992, 48, 4239, (synth)
• Murray, R.D.H. et al., The Natural Coumarins, J. Wiley, 1982, (rev)
• Hayakawa, K. et al., J.A.C.S., 1984, 106, 6735, (synth)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, FQD000
• Chatterjee, A. et al., Indian J. Chem., Sect. B, 1977, 15, 212, (synth, uv, pmr)
• Worden, L.R. et al., J.O.C., 1969, 34, 2311, (synth)
• Matsumoto, H. et al., Chem. Pharm. Bull., 1978, 26, 3433, (uv)
• Reisch, J. et al., Chem. Ber., 1979, 112, 1491, (synth)
• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 3, 173A, (nmr)
• Bergenthal, D. et al., Arch. Pharm. (Weinheim, Ger.), 1978, 311, 1026, (cmr)
• Pardanani, N.H. et al., Aust. J. Chem., 1972, 25, 1537, (synth)
• Austin, D.H. et al., Phytochemistry, 1973, 12, 1657, (biosynth)
• Beier, R.C. et al., Xenobiotics in Foods and Feeds, Amer. Chem. Soc., 1983, 295, (occur)
• Masuda, T. et al., Phytochemistry, 1998, 47, 13-16, (isol, uv, pmr, cmr)
• Chimichi, S. et al., Tetrahedron, 2002, 58, 4859-4863, (synth)