Substance
ID:449768
Names and Identifiers
IUPAC name
4-amino-N-(pyrimidin-2-yl)benzene-1-sulfonamide
Synonyms
SulfadiazineSulfadiazineTriple SulfasTriple SulfoidNeotrizineSulfaloidTerfonylLantrisulTriple SulfaSulfonamides DuplexSulfose
IUPAC Traditional name
4-amino-N-(pyrimidin-2-yl)benzene-1-sulfonamide
Registration numbers
CAS Number
Properties
Product Information
Application(s)
Used in some countries for control of bacterial disease in farmed fish
Antibacterial agent
Pharmacology Properties
Mechanism of Action
Folate synthesis inhibitor
Restrict folate synthesis through competitive antagonism of PABA
Folate antagonist
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
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• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 1477
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 201; 206
• Gehring, T.A. et al., J. Agric. Food Chem., 1996, 44, 3164-3169, (anal)
• Kokila, M.K. et al., Acta Cryst. C, 1995, 51, 333, (cryst struct)
• Bult, A., Pharm. Weekbl., Sci. Ed., 1983, 5, 77, (cmr, tautom)
• Roblin, R.O., J.A.C.S., 1940, 62, 2002, (synth)
• Kracmar, J. et al., Pharmazie, 1975, 30; 447, (uv)
• Joshi, V.V. et al., Indian J. Phys., A, 1983, 57, 79, (cryst struct)
• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 3, 392A, (nmr)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, MRM250; SNI425; PPP500
• Stober, H. et al., Anal. Profiles Drug Subst., 1982, 11, 523; 1984, 13, 553, (rev, synth, pharmacol, anal)
• Sigel, C.W., Handb. Exp. Pharmacol., 1983, 64, 163, (rev, metab)
• Bass, A.D., Drill's Pharmacol. Med., 4th edn., McGraw-Hill, New York, 1971, 1657, (rev, pharmacol)
• Cai, E., CA, 1982, 96, 57702, (synth)
• Przybylski, M. et al., Adv. Mass Spectrom. Biochem. Med., Proc. Int. Symp. Mass Spectrom. Biochem. Med. 2nd, 3rd, 1976, 1, 309, (ms)