Substance
ID:449758
Names and Identifiers
IUPAC name
4-amino-N-(1,3-thiazol-2-yl)benzene-1-sulfonamide
Synonyms
SulfathiazoleSultrin
IUPAC Traditional name
4-amino-N-(1,3-thiazol-2-yl)benzene-1-sulfonamide
Registration numbers
CAS Number
Properties
Product Information
Application(s)
Sulfonamide
Used in treatment of severe staphylococcal infections, but use restricted due to its systemic toxicity.
Pharmacology Properties
Mechanism of Action
Dihydrofolate reductase inhibitor
Dihydrofolate synthesis inhibitor
Folate-antagonist
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
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• Hughes, D.S. et al., Acta Cryst. C, 1999, 55, 1831-1833, (cryst struct)
• Bass, A.D. et al., Drill's Pharmacol. Med., 4th edn., McGraw-Hill, New York, 1971, 1657, (pharmacol)
• Haley, T.J., Dangerous Prop. Ind. Mater. Rep., 1983, 3, 9, (rev, pharmacol, tox)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 210
• Capitan, F. et al., Inf. Quim. Anal., 1970, 24, 100, (use)
• Kracmar, J. et al., Pharmazie, 1975, 30, 447, (uv)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 1148
• Fosbinder, R.J., J.A.C.S., 1939, 61, 2032, (synth)
• Forlani, L., Gazz. Chim. Ital., 1981, 111, 159, (pmr, tautom)
• Bult, A., Pharm. Weekbl., Sci. Ed., 1983, 5, 77, (cmr, tautom)
• Kirk-Othmer Encycl. Chem. Technol., 4th edn., Wiley, 1991, 2, 876, (rev)