Substance
ID:449756
Names and Identifiers
IUPAC name
4-amino-N-(5-methyl-1,2-oxazol-3-yl)benzene-1-sulfonamide
Synonyms
GantanolSulfamethoxazole
IUPAC Traditional name
4-amino-N-(5-methyl-1,2-oxazol-3-yl)benzene-1-sulfonamide
Registration numbers
CAS Number
Properties
Product Information
Application(s)
Used in treatment of respiratory and urinary tract infections
Sulfonamide bacteriostatic antibiotic
Pharmacology Properties
Mechanism of Action
Folate synthesis inhibitor
Restrict folate synthesis through competitive antagonism of PABA
Folate antagonist
Molecule Details
No Data Available
Click here to submit data
Molecular Spectra
No Data Available
Click here to submit data
References
• Bushby, S.R.M. et al., Handb. Exp. Pharmacol., 1983, 64, 75; 163; 185, (revs)
• Maury, L. et al., Can. J. Chem., 1985, 63, 3012, (cryst struct, ir, Raman)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, SNK000
• Brumfitt, W. et al., J. Infect. Dis., 1973, 128, 5778, (rev, pharmacol)
• Kirk-Othmer Encycl. Chem. Technol., 4th edn., Wiley, 1991, 2, 876
• Manzo, R.H. et al., J. Pharm. Sci., 1973, 62, 152, (uv)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 1514; 3212
• U.K. Pat., 1959, 814276; CA, 55, 20091c, (synth)
• Rudy, B.C. et al., Anal. Profiles Drug Subst., 1973, 2, 467, (rev, synth, props)
• Iwai, I. et al., Chem. Pharm. Bull., 1966, 14, 1277, (synth)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 208
• Fujimoto, M. et al., Chem. Pharm. Bull., 1962, 10, 572-575, (derivs)
• IARC Monog., 1980, 24, 285; Suppl. 7, 348; Suppl. 6, 502, (rev, tox)
• Bult, A., Pharm. Weekbl., Sci. Ed., 1983, 5, 77, (cmr, tautom)