Substance

ID:449744

Names and Identifiers
IUPAC name
methyl({3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl})amine
IUPAC Traditional name
methyl({3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl})amine
Synonyms
FluoxetineProzac
Registration numbers
CAS Number
Properties
Product Information
Application(s)
Psychostimulant
Used for the treatment of premenstrual dysphoric disorder.
Antidepressant
Pharmacology Properties
Mechanism of Action
Blocks the reuptake of serotonin at the serotonin reuptake pump of the neuronal membrane, enhancing the actions of serotonin on 5HT(1A) autoreceptors.
Selective serotonin-reuptake inhibitor (SSRI).
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• Lautz, R.J. et al., J. Chromatogr., 1993, 614, 175, (gc)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 7th edn., Akademie-Verlag, 1994, 5753
• Hilborn, J.W. et al., Tet. Lett., 2001, 42, 8919-8921, (synth)
• U.S. Pat., 1977, 4 018 895; CA, 87, 134520z, (synth, pharmacol)
• Lenberger, L. et al., J. Clin. Psychiatry, 1985, 46, 14, (pharmacol, metab)
• Benfield, P. et al., Drugs, 1986, 32, 481, (rev)
• Robertson, D.W. et al., J. Med. Chem., 1988, 31, 1412, (synth, abs config, resoln, pharmacol)
• Corey, E.J. et al., Tet. Lett., 1989, 30, 5207, (R-form, synth)
• Sakuraba, S. et al., Chem. Pharm. Bull., 1995, 43, 748, (synth)
• Wong, D.T. et al., Life Sci., 1995, 57, 411, (pharmacol, rev)
• Hisrich, K.R. et al., J. Pharm. Technol., 1987, 3, 219, (rev)
• Risley, D.S. et al., Anal. Profiles Drug Subst., 1990, 19, 193, (rev)
• Miles, W.H. et al., Tetrahedron, 2001, 57, 9925-9929, (synth)
• Gao, Y. et al., J.O.C., 1988, 53, 4081, (R-form, synth, abs config, ir, pmr)
• Gram, L., N. Engl. J. Med., 1994, 331, 1354, (pharmacol, rev)
• Cheer, S.M. et al., Drugs, 2001, 61, 81-110, (rev)
• Feighner, J.P. et al., Selective Serotonin Re-uptake Inhibitors, J. Wiley, 1991, (book)
• Mitchell, D. et al., Synth. Commun., 1995, 25, 1231, (synth)
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 284
• Ch^enevert, R. et al., Tetrahedron, 1992, 48, 6769, (R-form, S-form)
• Altamura, A.C. et al., Clin. Pharmacokinet., 1994, 26, 201, (rev, pharmacokinet)