Substance
ID:449734
Names and Identifiers
IUPAC name
5-amino-1-cyclopropyl-7-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-6,8-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
Synonyms
SparfloxacinZagamSpara
IUPAC Traditional name
5-amino-1-cyclopropyl-7-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-6,8-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
Registration numbers
CAS Number
Properties
Product Information
Application(s)
Leprostatic and antitubercular agent
Broad spectrum antibacterial agent
Pharmacology Properties
Mechanism of Action
Quinolones can enter cells easily and therefore are often used to treat intracellular pathogens such as Legionella pneumophila and Mycoplasma pneumoniae.
Eukaryotic cells do not contain DNA gyrase or topoisomerase IV.
For many gram-negative bacteria DNA gyrase is the target, whereas topoisomerase IV is the target for many gram-positive bacteria.
Inhibitor of bacterial DNA gyrase or the topoisomerase IV enzyme, thereby inhibiting DNA replication and transcription.
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• Lewin, C.S. et al., J. Antimicrob. Chemother., 1992, 30, 625, (activity)
• Shimada, J. et al., Clin. Pharmacokinet., 1993, 25, 358, (pharmacokinet, rev)
• Chaudhry, A.Z. et al., Antimicrob. Agents Chemother., 1990, 34, 1843; 2442, (activity)
• Kagemoto, A. et al., Arzneim.-Forsch., 1991, 41, 744, (synth)
• Matsunaga, Y. et al., Arzneim.-Forsch., 1991, 41, 747; 760, (metab)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 202
• Miyamoto, T. et al., J. Med. Chem., 1990, 33, 1645, (cryst struct, synth, pharmacol)
• Qadri, S.M. et al., Chemotherapy (Basel), 1992, 38, 99, (activity)
• Richard, P. et al., J. Antimicrob. Chemother., 1992, 30, 739, (rev)
• Nakamura, S. et al., Antimicrob. Agents Chemother., 1989, 33, 1167; 1990, 34, 89, (pharmacol, activity)
• Borner, K. et al., J. Chromatogr., 1992, 579, 285, (hplc)
• Goa, K.L. et al., Drugs, 1997, 54, 700-725, (rev)
• Drugs of the Future, 1989, 14, 413, (rev)
• Nogita, T. et al., J. Antimicrob. Chemother., 1991, 28, 313, (pharmacokinet)