Substance

ID:449716

Names and Identifiers
IUPAC name
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile
Synonyms
IsoptinIproveratrilBerkatensCordiloxEthimilUniverVasolanVerapressVerapamilCoveraGeanginVerelanSecuronCalan
IUPAC Traditional name
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile
Registration numbers
CAS Number
Properties
Pharmacology Properties
Mechanism of Action
Calcium antagonist
Inhibits movement of calcium ions across the cell membrane
Protein kinase C inhibitor
Product Information
Application(s)
Coronary vasodilator
Smooth muscle relaxant.
Used in the treatment of hypertension, angina pectoris, cardiac arrhythmia, and cluster headaches.
Antiarrhythmic (class IV) agent
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• Guerrero, J.R. et al., Med. Res. Rev., 1984, 4, 87, (rev)
• Carpy, A. et al., Acta Cryst. C, 1985, 41, 624, (cryst struct)
• Chang, Z.L., Anal. Profiles Drug Subst., 1988, 17, 643, (rev)
• Hofer, C.A. et al., Am. J. Med., 1993, 95, 431, (tox)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, IRV000; VHA450
• Larangh, J.H., Am. J. Cardiol., Ed., Part 7, 1986, 57, (book)
• Echizen, H. et al., Clin. Pharmacokinet., 1986, 11, 425, (rev)
• Dooley, M. et al., Drugs, 1998, 56, 837-844, (rev)
• Baky, S.H. et al., Pharmacol. Biochem. Prop. Drug Subst., 1981, 3, 226, (rev, pharmacol)
• Scheid, W. et al., Arzneim.-Forsch., 1991, 41, 901, (tox)
• Longstreth, J.A., Drug Stereochem., (Ed. Wainer, I.W.), M. Dekker, 1993, 315, (rev)
• Bannister, R.M. et al., Org. Process Res. Dev., 2000, 4, 467-472, (synth, pmr)
• Theodore, L.J. et al., J.O.C., 1987, 52, 1309, (synth)
• Knoll, A.G., Angew. Chem., Int. Ed., 1964, 3, 68, (synth, pharmacol)
• Ger. Pat., 1978, 2 631 222; CA, 88, 169796, (synth)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 7th edn., Akademie-Verlag, 1994, 10669; 10670
• Brogden, R.N. et al., Drugs, 1996, 51, 792, (rev)
• Brenna, E. et al., Eur. J. Org. Chem., 2001, 1349-1357, (synth)
• Ramuz, H., Helv. Chim. Acta, 1975, 58, 2050, (synth, ir, ms, pmr, abs config)
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 960