Substance
ID:449711
Names and Identifiers
IUPAC name
1-(diphenylmethyl)-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine
Synonyms
CinnarizineMitronalAplactanStugeron
IUPAC Traditional name
1-(diphenylmethyl)-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine
Registration numbers
CAS Number
Properties
Pharmacology Properties
Mechanism of Action
Calcium antagonist
Reported Proton pump uncoupler
Reported to inhibit cardiac liposomal lipid peroxidation mediated by the xanthine oxidase system
Histamine H 1 receptor antagonist
Reported catecholamine depletor
Reported inhibitor of bioenergetics of chromaffin granule ghosts
Reported Mg-atpase inhibitor
Product Information
Application(s)
Cerebral blood flow improver used for treatment of apoplexy and arteriosclerosis
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• Belg. Pat., 1960, 556 791; CA, 1960, 54, 590
• Cotrait, M. et al., Acta Cryst. B, 1975, 31, 1495, (cryst struct)
• Spedding, M., Naunyn-Schmiedeberg's Arch. Pharmacol., 1982, 318, 234, (pharmacol)
• Yao, F. et al., CA, 1984, 101, 211103, (synth)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, CMR100; CMS125
• Towse, G., Int. Congr. Symp. Ser. R. Soc. Med., (Ed.), 1980, 33, (book)
• U.K. Pat., 1960, 809 760; CA, 1960, 54, 2379, (synth)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 934
• Gotfraind, T. et al., Drugs of Today (Barcelona), 1982, 18, 27, (rev, pharmacol)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 7401, (synonyms)