Substance
ID:449706
Names and Identifiers
IUPAC name
1-[bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine
Synonyms
4',4''-Difluorocinnarizine1-[Bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)piperazineFlunarizine
IUPAC Traditional name
1-[bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine
Registration numbers
CAS Number
Properties
Pharmacology Properties
Mechanism of Action
Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity
Calcium channel blocker
Product Information
Application(s)
Effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy.
It may help to reduce the severity and duration of attacks of paralysis associated with the more serious form of alternating hemiplegia.
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• Marini, D. et al., Boll. Chim. Farm., 1984, 123, 133, (struct, uv, ir)
• Ger. Pat., 1972, 2 220 242; CA, 78, 29815r, (synth)
• Amery, W.K. et al., Drugs Exp. Clin. Res., 1981, 7, 1, (pharmacol)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 7382, (synonyms)
• Xiang, M. et al., CA, 1985, 102, 78835, (synth)
• Schmidt, R. et al., J. Cardiovasc. Pharmacol., (Suppl. 8), 1991, 18, S27, (rev)
• Holmes, B. et al., Drugs, 1984, 29, 6, (rev, pharmacol)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 939
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, FDD080