Substance
ID:449704
Names and Identifiers
IUPAC name
(Z)-3-[({2-[(diaminomethylidene)amino]-1,3-thiazol-4-yl}methyl)sulfanyl]-N'-sulfamoylpropimidamide
Synonyms
GastridinPepcidacPepdineGanorFamodilMotiaxPepdulFamotidineGasterPepcidPepcidineAmifatidine
IUPAC Traditional name
(Z)-3-[({2-[(diaminomethylidene)amino]-1,3-thiazol-4-yl}methyl)sulfanyl]-N'-sulfamoylpropimidamide
Registration numbers
CAS Number
Properties
Pharmacology Properties
Mechanism of Action
Histamine H 2 receptor antagonist
Weak pepsin inhibitor
Gastric secretion inhibitor
Product Information
Application(s)
Suggested beneficial effect in treatment of schizophrenia.
Used in treatment of gastric and duodenal ulcers, gastro-oesophageal reflux disease and Zollinger-Ellison syndrome.
Antiviral agent
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• Oyewumi, L.K. et al., J. Psychiatry Neurosci., 1994, 19, 145; 20, 239, (use)
• J. Int. Med. Res., Suppl. 1, 1989, 17, 1A, (rev)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, FAB500
• Katsura, Y. et al., Chem. Pharm. Bull., 1992, 40, 2432, (analogues, activity)
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 1192
• Golic, L. et al., Acta Cryst. C, 1989, 45, 1381, (cryst struct)
• Ger. Pat., 1980, Yamanouchi, 3 008 056; CA, 94, 156916e, (synth, pharmacol)
• Takagi, T. et al., Arch. Int. Pharmacodyn. Ther., 1982, 256, 49, (pharmacol)
• Wanwimolruk, S. et al., J. Chromatogr., 1991, 572, 227, (hplc)
• Imai, Y. et al., Biomed. Chromatogr., 1992, 6, 222, (hplc)
• Langtry, H.D. et al., Drugs, 1989, 38, 551, (rev)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 7th edn., Akademie-Verlag, 1994, 1216, (synonyms)