Substance

ID:449684

Names and Identifiers
IUPAC name
N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide
Synonyms
DogmatilEglonylMirbanilDogmatylSulpirideMilsulvan
IUPAC Traditional name
N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide
Registration numbers
CAS Number
Properties
Pharmacology Properties
Mechanism of Action
In contrast to most other neuroleptics which block both dopamine D1 and D2 receptors, Sulpiride is more selective and acts primarily as a dopamine D2 antagonist
Sulpiride appears to lack effects on norepinephrine, acetylcholine, serotonin, histamine, or gamma-aminobutyric acid (GABA) receptors
Dopamine D2-receptor antagonist
Product Information
Application(s)
Digestive aid
Antianxiety drug
Migraine therapeutic
Antidepressant
Non-sedative major antipsychotic agent
Low acute toxicity
Molecule Details
No Data Available
Click here to submit data
Molecular Spectra
No Data Available
Click here to submit data
References
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, EPD500
• Ger. Pat., 1976, 2 365 832; CA, 85, 142976b, (synth)
• van de Waterbeemd, H. et al., Helv. Chim. Acta, 1981, 64, 2183, (cd, pharmacol)
• O'Connor, S.E. et al., Gen. Pharmacol., 1982, 13, 185, (rev, pharmacol)
• Jenner, P. et al., Neuropharmacology, 1981, 20, 1285, (rev, activity)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 3746
• Montanaro, N. et al., Adv. Biochem. Psychopharmacol., 1982, 31, 341, (activity)
• Maury, L. et al., Can. J. Chem., 1987, 65, 1613, (ir, struct)
• Pitre, D. et al., Anal. Profiles Drug Subst., 1988, 17, 607, (rev)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 615
• Ma, L.Y.Y. et al., Acta Cryst. B, 1982, 38, 2861, (cryst struct, abs config, bibl)
• Pitre, D. et al., Arch. Pharm. (Weinheim, Ger.), 1987, 320, 859, (phys props)
• Al-Koutayni-Rifai, M. et al., J. Labelled Compd. Radiopharm., 1989, 27, 811, (synth)
• Costall, B. et al., Psychopharmacologia, 1975, 43, 69, (pharmacol)
• Miller, J.D. et al., Life Sci., 1987, 41, 1815, (pharmacol)
• Serra, G. et al., Adv. Biosci. (Oxford), 1990, 77, 185, (rev, props)