Substance

ID:449680

Names and Identifiers
Synonyms
TarividOflocetOxaldinOfloxacinFlobacinExocinOcufloxOflocinMefoxacin
IUPAC name
7-fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid
IUPAC Traditional name
7-fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid
Registration numbers
CAS Number
82419-36-1
Properties
Product Information
Application(s)
Shows broad spectrum of activity against gram-positive and -negative bacteria
Antibacterial agent
Antiseptic
Pharmacology Properties
Mechanism of Action
DNA gyrase inhibitor
Molecule Details
No Data Available
Click here to submit data
Molecular Spectra
No Data Available
Click here to submit data
References
• Monk, J.P. et al., Drugs, 1987, 33, 346, (rev)
• Langtry, H.D. et al., Drugs, 1998, 56, 487-515; 895-928, (rev)
• New Gener. Quinolones, 1990, (Eds. Siporin, C. et al), M. Dekker (see Infect. Dis. Ther. v5 1990), 1990, (book)
• Sanders, C.C., Clin. Infect. Dis., 1992, 14, 526, (rev)
• Lamp, K.C. et al., Clin. Pharmacokinet., 1992, 22, 32, (pharmacokinet, rev)
• Todd, P.A. et al., Drugs, 1991, 42, 825, (rev)
• Davis, R. et al., Drugs, 1994, 47, 677, (rev)
• Kitaoka, H. et al., Chem. Pharm. Bull., 1995, 43, 649, (cryst struct, props)
• Mitscher, L.A. et al., J. Med. Chem., 1987, 30, 2283, (synth, activity)
• Tunkel, A.R. et al., Infect. Control Hosp. Epidemiol., 1991, 12, 549, (activity, rev)
• Eur. Pat., 1982, Daiichi Seiyaku, 47 005; CA, 97, 55821b, (synth, pharmacol)
• Egawa, H. et al., Chem. Pharm. Bull., 1986, 34, 4098, (synth)
• The 4-Quinolones: Antibacterial Agents in Vitro, (Ed. Crumplin, G.C.), Springer-Verlag, London, 1990, (book)
• Sato, K. et al., Antimicrob. Agents Chemother., 1982, 22, 548, (pharmacol)
• Hayakawa, I. et al., Antimicrob. Agents Chemother., 1986, 29, 163, (resoln, props)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 7th edn., Akademie-Verlag, 1994, 6400; 6401, (synonyms)
• Hashimoto, K. et al., Acta Cryst. C, 1995, 51, 519
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, OGI300
• Atarashi, S. et al., J. Het. Chem., 1991, 28, 329, (synth)
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 221; 233
Navigation