Substance
ID:449674
Names and Identifiers
IUPAC name
5-fluoro-1-(oxolan-2-yl)-1,2,3,4-tetrahydropyrimidine-2,4-dione
Synonyms
FtorafurTegafurCitofurSinoflurolFurflucilNeberkFutraful
IUPAC Traditional name
5-fluoro-1-(oxolan-2-yl)-1,2,3,4-tetrahydropyrimidine-2,4-dione
Registration numbers
CAS Number
Properties
Pharmacology Properties
Mechanism of Action
Thymidylate synthetase inhibitor
RNA synthesis inhibitor
Fluorouracil prodrug
DNA synthesis inhibitor
Product Information
Application(s)
Cytostatic
Antineoplastic agent
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• Ozaki, S. et al., Chem. Pharm. Bull., 1986, 34, 150, (synth)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 878
• Nakai, Y. et al., Chem. Pharm. Bull., 1982, 30, 2629; 1986, 34, 1242, (cryst struct, bibl)
• Loo, T.L. et al., Drug Metab. Rev., 1978, 8, 137, (metab, rev)
• Fujimoto, S., Drugs of Today (Barcelona), 1985, 21, 125, (rev, pharmacol)
• Uchida, T. et al., Chem. Pharm. Bull., 1993, 41, 1632, (polymorphism)
• Aldrich Library of FT-IR Spectra, 1st edn., 1985, 2, 811D, (ir)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, FMB000; UNJ810
• Yamamoto, S. et al., Arzneim.-Forsch., 1981, 31, 1268, (pharmacol)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 502
• Yasumoto, M. et al., J. Med. Chem., 1977, 20, 1592, (synth, resoln)
• Au, J. et al., Cancer Chemother. Pharmacol., 1981, 7, 55, (metab)
• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 3, 366A, (nmr)