Substance
ID:449664
Names and Identifiers
IUPAC name
2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethan-1-ol
Synonyms
MetronidazoleElyzolFlagylMetrotopMidazolTorgylZadstat
IUPAC Traditional name
2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethan-1-ol
Registration numbers
CAS Number
Properties
Product Information
Application(s)
Amebiasis, symptomatic and asymptomatic trichomoniasis; skin and skin structure infections; CNS infections; intra-abdominal infections (as part of combination regimen);
systemic anaerobic infections; treatment of antibiotic-associated pseudomembranous colitis (AAPC), bacterial vaginosis
Antiprotozoal, antibacterial and amoebicidal agent
Treatment of susceptible anaerobic bacterial and protozoal infections in the following conditions:
as part of a multidrug regimen for H. pylorieradication to reduce the risk of duodenal ulcer recurrence
Pharmacology Properties
Mechanism of Action
After diffusing into the organism, interacts with DNA to cause a loss of helical DNA structure and strand breakage resulting in inhibition of protein synthesis and cell death in susceptible organisms
Molecule Details
No Data Available
Click here to submit data
Molecular Spectra
No Data Available
Click here to submit data
References
• Aldrich Library of FT-IR Spectra, 1st edn., 1985, 2, 619B, (ir)
• Scully, B.E., Med. Clin. North Am., 1988, 72, 613, (rev, pharmacol)
• Freeman, C.D. et al., Drugs, 1997, 54, 679-708, (rev)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, MMN250
• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 3, 84B, (nmr)
• IARC Monog., 1977, 13, 113; Suppl. 7, 250; Suppl. 6, 399, (rev, tox)
• Ross, W.J. et al., J. Med. Chem., 1972, 15, 1035, (pharmacol)
• Wearley, L.L. et al., Anal. Profiles Drug Subst., 1976, 5, 327, (rev)
• Edwards, D.I., Antibiotics (N.Y.), 1983, 6, 121, (rev, pharmacol)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 516
• Stambaugh, J.E. et al., Can. J. Spectrosc., 1968, 13, 134, (ir, nmr)
• Ger. Pat., 1978, BASF, 2 718 192; CA, 90, 87453e
• McKillop, A. et al., Tetrahedron, 1983, 39, 3797, (cmr)
• Cossar, B.C. et al., Arzneim.-Forsch., 1966, 16, 23, (synth)
• Rosenblatt, J.E. et al., Mayo Clin. Proc., 1987, 62, 1013, (rev)
• Phillips, I. et al., Int. Congr. Symp. Ser. R. Soc. Med., (Eds.), No. 18: Metronidazole, Academic Press, N.Y., 1979, (book)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 480; 2721, (synonyms)