Substance
ID:449655
Names and Identifiers
IUPAC name
9-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]-9H-purin-6-ol
IUPAC Traditional name
9-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]-9H-purin-6-ol
Synonyms
2',3'-Dideoxy-1,9-dihydro-9-beta- D -ribofuranosyl-6 H -purin-6-one; 2',3'-DideoxyinosineVidexDidanosine
Registration numbers
CAS Number
Properties
Product Information
Application(s)
Potentially of use against HIV infection and used in combination with other antiretroviral drug therapy as part of highly active
Nucleoside transporter substrate.
Antiviral agent
Pharmacology Properties
Mechanism of Action
Reverse Transcriptase inhibitor
Cell proliferation inhibitor
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• Ray, G. et al., Anal. Lett., 1987, 20, 1815, (hplc)
• Chu, C.K. et al., J.O.C., 1989, 54, 2217, (synth, pmr)
• McGowan, J.J. et al., Rev. Infect. Dis., 1990, 12, S513, (rev, antiretroviral props)
• Nassar, M.N. et al., Anal. Profiles Drug Subst., 1993, 22, 185, (rev)
• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 3, 215B, (nmr)
• Wu, X. et al., J. Biol. Chem., 1992, 267, 8813-8818, (pharmacol)
• Bhat, V. et al., Synth. Commun., 1992, 22, 1481, (synth, pmr, uv)
• Mitsuya, H. et al., Proc. Natl. Acad. Sci. U.S.A., 1986, 83, 1911, (pharmacol)
• Shelton, M.J. et al., Ann. Pharmacother., 1992, 26, 660, (rev)
• Hao, Z. et al., Mol. Pharmacol., 1988, 34, 431, (pharmacol)
• Ahluwalia, G. et al., Biochem. Pharmacol., 1987, 36, 3797