Substance
ID:449649
Names and Identifiers
IUPAC name
(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione
Synonyms
CurcuminDiferuloylmethaneCurcuma yellow
IUPAC Traditional name
(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione
Registration numbers
CAS Number
Properties
Product Information
Application(s)
Antitumor
Antiarthritic
Antiamyloid
Possesses bactericidal and fungicidal props.
Antiinflammatory agent
Bile stimulant showing hepatoprotective props
Biological Source
Isol. from Curcuma zedoaria (turmeric), other Curcuma spp. and other spp.
Description
Tautomers
Pharmacology Properties
Mechanism of Action
Inhibitor of eicosanoid biosynthesis
Acts as a free radical scavenger and antioxidant, inhibiting lipid peroxidation and oxidative DNA damage
Induce glutathione S-transferase and are potent inhibitors of cytochrome P450;
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• Aldrich Library of FT-IR Spectra, 1st edn., 1985, 2, 52C, (ir)
• Spicer, G.S. et al., Anal. Chim. Acta, 1958, 18, 231, (detn, B)
• Umland, F. et al., Fresenius' Z. Anal. Chem., 1963, 197, 151, (detn, Ni)
• Sastry, B.S., Res. Ind., 1970, 15, 258; CA, 75, 75063e, (isol)
• Quint, P. et al., Fresenius' Z. Anal. Chem., 1977, 285, 356; 1979, 295, 269, (detn, B)
• Roughley, P.J. et al., J.C.S. Perkin 1, 1973, 2379-2388, (biosynth)
• Kashina, C. et al., Heterocycles, 1977, 7, 241, (synth)
• Karig, F., Dtsch. Apoth. -Ztg., 1975, 115, 325; CA, 83, 65372f, (derivs)
• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 2, 800B, (nmr)
• Kuroyagi, M. et al., Yakugaku Zasshi, 1970, 90, 1467; CA, 74, 61612a, (isol)
• Dyrssen, D.W. et al., Anal. Chim. Acta, 1972, 60, 139, (detn, B)
• Lampe, V., Ber., 1918, 51, 1347, (synth)
• Cheng, K.L. et al., Handbook of Organic Analytical Reagents, CRC Press, Boca Raton, 1982, 511, (use)
• Jentzsch, K. et al., Sci. Pharm., 1968, 36, 251; CA, 70, 90793h, (isol)
• Holder, G.M. et al., Xenobiotica, 1978, 8, 761, (metab)
• Ammon, H.P.T. et al., Planta Med., 1991, 57, 1-7, (rev, pharmacol)
• Jitoe, A. et al., J. Agric. Food Chem., 1992, 40, 1337-1340, (occur)
• Wahlstrom, B. et al., Acta Pharmacol. Toxicol., 1978, 43, 86, (metab)
• Srinivasan, K.R., J. Pharm. Pharmacol., 1953, 5, 448, (derivs)
• Tonnesen, H.H. et al., Acta Chem. Scand., Ser. B, 1982, 36, 475, (cryst struct, bibl)