Substance
ID:449647
Names and Identifiers
IUPAC name
2-[2-hydroxy-5-(prop-2-en-1-yl)phenyl]-4-(prop-2-en-1-yl)phenol
Synonyms
Magnolol
IUPAC Traditional name
2-[2-hydroxy-5-(prop-2-en-1-yl)phenyl]-4-(prop-2-en-1-yl)phenol
Registration numbers
CAS Number
Properties
Pharmacology Properties
Mechanism of Action
CNS depressant with serotonergic activity
Reported from in-vitro study in rat aorta to produce relaxation of vascular smooth-muscle mediated by: release of endothelium derived relaxant factor
Inhibition of calcium influx through voltage gated channels
Product Information
Application(s)
Antibacterial, antifungal agent
Antiplatelet agent
Sedative
Relaxant
Shows antiinflammatory and analgesic effects
Biological Source
Constit. of Sassafras randaiense and Magnolia spp.
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• El-Feraly, F.S. et al., J. Nat. Prod., 1983, 46, 493
• Hattori, M. et al., Chem. Pharm. Bull., 1984, 32, 5010; 1986, 34, 158, (metab)
• Ho, T.I. et al., CA, 1986, 105, 152803, (synth)
• Watanabe, K. et al., Planta Med., 1983, 49, 103, (isol, pharmacol)
• Teng, C.-M. et al., Thromb. Res., 1988, 50, 757, (pharmacol)
• Wang, Y. et al., J. Chin. Chem. Soc. (Peking), 1982, 30, 215, (cryst struct)
• Kim, Y.-K. et al., Planta Med., 1996, 65, 291-292, (activity)
• Clark, A.M. et al., J. Pharm. Sci., 1981, 70, 951, (props)
• Wang, J.-P. et al., Naunyn-Schmiedeberg's Arch. Pharmacol., 1992, 346, 707, (pharmacol)
• Agharahimi, M.R. et al., J.O.C., 1995, 60, 1856, (synth, ir, pmr, cmr, ms)
• Runeberg, J. et al., Acta Chem. Scand., 1957, 11, 1060; 1958, 12, 188
• Tsai, T.-H. et al., Neurosci. Lett., 1995, 186, 49, (pharmacol)
• Tsai, T.-H. et al., Drug Metab. Dispos., 1994, 22, 518, (hplc, pharmacokinet)