Substance

ID:449640

Names and Identifiers
Synonyms
OestroneEstroneOxohydroxyoestrinProgynonMenformonOestrinFollicular hormone
IUPAC Traditional name
(1S,10R,11S,15S)-5-hydroxy-15-methyltetracyclo[8.7.0.02,7.011,15]heptadeca-2(7),3,5-trien-14-one
IUPAC name
(1S,10R,11S,15S)-5-hydroxy-15-methyltetracyclo[8.7.0.02,7.011,15]heptadeca-2(7),3,5-trien-14-one
Registration numbers
CAS Number
53-16-7
Properties
Product Information
Application(s)
Used therapeutically in combination with other natural estrogens
Biological Source
Obt. from human pregnancy urine and from pregnant mares' urine. Also a trace constit. of plant tissues, e.g. seeds of date (Phoenix dactylifera) and pomegranate (Punica granatum)
Pharmacology Properties
Mechanism of Action
Estrogen
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• Busetta, B. et al., C. R. Hebd. Seances Acad. Sci. Ser. C, 1972, 274, 153, (cryst struct)
• Posner, G.H. et al., Tetrahedron, 1981, 37, 3921, (synth)
• Both, D., Anal. Profiles Drug Subst., 1983, 12, 135, (rev)
• Barlaam, B. et al., Tet. Lett., 1991, 32, 623, (synth)
• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 3, 589C, (nmr)
• Kuo, C.H. et al., Chem. Ind. (London), 1966, 1340, (synth)
• Crabb, P. et al., Can. J. Chem., 1968, 46, 349, (14 synth, uv, ir)
• IARC Monog., 1979, 21, 343, (tox, rev)
• Quinkert, G. et al., Annalen, 1981, 2335, (synth)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 4875; 4883
• Caspi, E. et al., Chem. Comm., 1989, 1302, (biosynth)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 1183; 1192
• Hiraga, K. et al., Chem. Comm., 1969, 1013, (synth)
• Wittstruck, T.A. et al., J.O.C., 1973, 38, 1542, (cmr)
• Birch, A.J. et al., Aust. J. Chem., 1970, 23, 547, (synth)
• Crispin, D.J. et al., J.C.S.(C), 1970, 10, (synth)
• Sergeev, P.V. et al., Zh. Fiz. Khim., 1973, 47, 1643, (ms)
• Cohen, N. et al., J.O.C., 1975, 40, 681, (synth)
• Kametani, T. et al., J.A.C.S., 1976, 98, 3378; 1977, 99, 3461, (synth)
• Danishefsky, S. et al., J.A.C.S., 1976, 98, 4975, (synth)
• Duax, W.L. et al., Acta Cryst. B, 1979, 35, 2656, (cryst struct)
• Hutchinson, J.H. et al., Can. J. Chem., 1987, 65, 1, (synth)
• Taber, D.F. et al., J.O.C., 1987, 52, 28, (synth)
• Takano, S. et al., Tet. Lett., 1992, 33, 1909, (synth)
• Tanaka, K. et al., Org. Lett., 2000, 1915-1917, (synth)
• Aldrich Library of FT-IR Spectra, 1st edn., 1985, 2, 1055D, (ir)
• Heftmann, E. et al., Phytochemistry, 1966, 5, 231; 1337, (isol)
• Ziegler, F.E. et al., Tet. Lett., 1981, 1179, (synth)
• Zepter, R., J. Prakt. Chem., 1971, 313, 1139, (synth, uv, pmr)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, EDV000; EDV600
• Rufer, C. et al., Annalen, 1967, 705, 211, (synth)
• Sugahara, T. et al., Tet. Lett., 1996, 37, 7403, (synth)
• Smales, C.M. et al., Acta Cryst. C, 1997, 53, 1082-1084, (cryst struct)
• Douglas, G.H. et al., J.C.S., 1963, 5072, (synth, ir)
• Nicolaou, K.C. et al., J.O.C., 1980, 45, 1403, (synth)
• Grieco, P.A. et al., J.O.C., 1980, 45, 2247, (synth)
• Sunder, N.M. et al., J.C.S. Perkin 1, 1990, 1331, (synth)
• Subba Rao, G.S.R. et al., Aust. J. Chem., 1992, 45, 187, (synth)
• Nicolaou, K.C. et al., Classics in Total Synthesis, Targets, Strategies, Methods, VCH, 1996, 153, (bibl, synth)
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