Substance
ID:449638
Names and Identifiers
Synonyms
1-DehydrocortisolPrednisoloneHydeltraDelta-Cortef
IUPAC name
(1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-5-one
IUPAC Traditional name
(1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-5-one
Registration numbers
CAS Number
Properties
Pharmacology Properties
Mechanism of Action
On binding, the corticoreceptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes.
Glucocorticoid receptor agonist.
The DNA bound receptor then interacts with basic transcription factors, causing an increase or decrease in expression of specific target genes, including suppression of IL2 (interleukin 2) expression.
Product Information
Application(s)
Antineoplastic agent
Adrenergic agent
Antiinflammatory agent
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
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• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, AAF625; PMA000; PMA100; SOV100; PLY300
• Kirk, D.N. et al., J.C.S. Perkin 2, 1990, 1567, (pmr)
• Zicha, L. et al., Arzneim.-Forsch., 1960, 10, 728; 831, (pharmacol, derivs)
• Jusko, W.J. et al., Ther. Drug Monit., 1980, 2, 169, (rev, pharmacol)
• Gonzalez, M.D. et al., Org. Magn. Reson., 1984, 22, 586, (cmr)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 6297; 6321; 6941
• Herzog, H.L. et al., Tetrahedron, 1962, 18, 581, (synth)
• Toft, P. et al., Can. J. Spectrosc., 1970, 15, 137, (ms)
• Gambertoglis, J.G. et al., J. Pharmacokinet. Biopharm., 1980, 8, 1, (rev, pharmacol)
• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 3, 585B, (nmr)
• Nobile, A. et al., J.A.C.S., 1955, 77, 4184, (biosynth)
• Herzog, H.L. et al., Science (Washington, D.C.), 1955, 121, 176, (struct)
• Hirschmann, R. et al., J.A.C.S., 1964, 86, 3903, (synth)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 737