Substance
ID:449628
Names and Identifiers
IUPAC name
2-[(1S,2R,10S,11S,14R,15S)-14-hydroxy-2,15-dimethyl-5,17-dioxotetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-14-yl]-2-oxoethyl acetate
Synonyms
CortancylDelcortinPrednisone acetateDelta-CorlinNisone
IUPAC Traditional name
2-[(1S,2R,10S,11S,14R,15S)-14-hydroxy-2,15-dimethyl-5,17-dioxotetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-14-yl]-2-oxoethyl acetate
Registration numbers
CAS Number
Properties
Pharmacology Properties
Mechanism of Action
Glycogen deposition inhibitor
Calcium mobilizer
ACTH antagonist
ACTH secretion inhibitor
Corticosteroid
Gluconeogenesis promoter
Phosphorus mobilizer
Product Information
Biological Source
Obt. from pregn-4-ene-3,11,20-trione by incubation with Corynebacterium simplex
Application(s)
Immunosuppressive
Antiinflammatory
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• Pickup, M.E., Clin. Pharmacokinet., 1979, 4, 111, (rev)
• Gambertoglio, J.G. et al., J. Pharmacokinet. Biopharm., 1980, 8, 1, (rev)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 6213
• Nobile, A. et al., J.A.C.S., 1955, 77, 4184, (synth)
• Tseikinskii, V.M. et al., Bioorg. Khim., 1979, 5, 1677, (cryst struct)
• Hickey, J.P. et al., J. Magn. Reson., 1980, 38, 501, (cmr)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 738
• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 3, 587B, (nmr)
• Gardi, R. et al., Gazz. Chim. Ital., 1963, 93, 431, (ir, uv)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, PLZ000; PLZ100
• Herzog, H.L. et al., Science (Washington, D.C.), 1955, 121, 176, (struct)
• Herzog, H.L. et al., Tetrahedron, 1962, 18, 581, (synth)