Substance

ID:449625

Names and Identifiers
IUPAC name
4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-1,2-dihydropyrimidin-2-one
Synonyms
EpivirZeffixLamivudine
IUPAC Traditional name
4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-1,2-dihydropyrimidin-2-one
Registration numbers
CAS Number
Properties
Product Information
Application(s)
Active against hepatitis B virus and human immunodeficiency virus
Potent antiviral agent
Pharmacology Properties
Mechanism of Action
HIV reverse transcriptase inhibitor
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
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• Schinazi, R.F. et al., Antimicrob. Agents Chemother., 1992, 36, 672, (pharmacol)
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• Harris, R.K. et al., J.C.S. Perkin 1, 1997, 2653-2659, (cryst struct, ir, cmr, pmr)
• Humber, D.C. et al., Tet. Lett., 1992, 33, 4625, (synth, bibl)
• Coates, J.A.V. et al., Antimicrob. Agents Chemother., 1992, 36, 202, (pharmacol)
• Perry, C.M. et al., Drugs, 1997, 54, 657-680, (rev)
• Eur. Pat., 1992, Glaxo, 517 145; CA, 118, 191756p, (synth, cryst struct)
• Soudeyns, H. et al., Antimicrob. Agents Chemother., 1991, 35, 1386, (pharmacol)
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• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 622
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• Storer, R. et al., Nucleosides Nucleotides, 1993, 12, 225, (synth, abs config)