Substance
ID:449622
Names and Identifiers
IUPAC name
(1S,2R,10S,11S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-diene-5,17-dione
Synonyms
Prednisone
IUPAC Traditional name
(1S,2R,10S,11S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-diene-5,17-dione
Registration numbers
CAS Number
Properties
Pharmacology Properties
Mechanism of Action
Gluconeogenesis promoter
ACTH antagonist
ACTH secretion inhibitor
Corticosteroid
Glycogen deposition inhibitor
Calcium mobilizer
Phosphorus mobilizer
Product Information
Application(s)
Immunosuppressive
Antiinflammatory
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• Nobile, A. et al., J.A.C.S., 1955, 77, 4184, (synth)
• Ger. Pat., 1960, 1 090 208; CA, 55, 26044b, (sulfate)
• Ger. Pat., 1960, 1 089 755; CA, 55, 20008, (succinate)
• Herzog, H.L. et al., Tetrahedron, 1962, 18, 581, (synth)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 6213
• Gambertoglio, J.G. et al., J. Pharmacokinet. Biopharm., 1980, 8, 1, (rev)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, PLZ000; PLZ100
• Herzog, H.L. et al., Science (Washington, D.C.), 1955, 121, 176, (struct)
• Gardi, R. et al., Gazz. Chim. Ital., 1963, 93, 431, (ir, uv)
• Hickey, J.P. et al., J. Magn. Reson., 1980, 38, 501, (cmr)
• Pickup, M.E., Clin. Pharmacokinet., 1979, 4, 111, (rev)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 738
• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 3, 587B, (nmr)