Substance

ID:449621

Names and Identifiers
Synonyms
Kendall's compound FHydrocortisoneReichstein's Substance M;CortefHydrocortoneEfcortelan;FicortrilHydrocortalHytoneCortenemaCortisol;11beta,17alpha,21-Trihydroxyprogesterone
IUPAC name
(1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.02,7.011,15]heptadec-6-en-5-one
IUPAC Traditional name
(1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.02,7.011,15]heptadec-6-en-5-one
Registration numbers
CAS Number
50-23-7
Properties
Pharmacology Properties
Mechanism of Action
Phosphorus mobilizer
Gluconeogenesis promoter
Glycogen deposition inhibitor
ACTH secretion inhibitor
Calcium mobilizer
Glucocorticoid
Product Information
Application(s)
Topical antiinflammatory agent
Antiallergic
Immunosuppressive
Biological Source
Adrenal cortical hormone
Molecule Details
No Data Available
Click here to submit data
Molecular Spectra
No Data Available
Click here to submit data
References
• van der Sijde, D. et al., Rec. Trav. Chim. (J. R. Neth. Chem. Soc.), 1966, 85, 721, (synth)
• Zaffaroni, A. et al., J.A.C.S., 1951, 73, 1390, (biosynth)
• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 3, 584C, (nmr)
• v. Euw, J. et al., Helv. Chim. Acta, 1942, 25, 988, (struct)
• Reichstein, T., Helv. Chim. Acta, 1937, 20, 953, (isol)
• Shirasaka, M., Chem. Pharm. Bull., 1961, 9, 152, (synth)
• Saucy, G. et al., Helv. Chim. Acta, 1966, 49, 1529; 1967, 50, 1394, (synth, ir, uv, pmr)
• Haskins, N.J. et al., Biomed. Mass Spectrom., 1974, 1, 423, (ms)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, BAV275; HHR000; CNS750; HHQ800; HHQ825; HHQ850; HHQ875
• Fiegel, G., Arzneim.-Forsch., 1975, 25, 560, (use)
• Kirk, D.N. et al., J.C.S. Perkin 2, 1990, 1567, (pmr)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 6346; 6986; 7335
• Genard, P., Org. Mass Spectrom., 1979, 12, 396, (pmr)
• Castellano, E.E. et al., Acta Cryst. B, 1980, 36, 3063, (cryst. struct)
• Minagawa, K. et al., J.C.S. Perkin 1, 1988, 587, (synth)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 734
• Smit, A. et al., Rec. Trav. Chim. (J. R. Neth. Chem. Soc.), 1966, 85, 731, (synth, struct, pmr)
• Bhacca, N.S. et al., J.A.C.S., 1973, 95, 8421, (cmr)
• Florey, K., Anal. Profiles Drug Subst., 1983, 12, 277, (rev, synth, pharmacol, anal)
Navigation