Substance
ID:449577
Names and Identifiers
Synonyms
LuteololLuteolinDigitoflavoneDaphneflavonolFlavopurpol
IUPAC name
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one
IUPAC Traditional name
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one
Registration numbers
CAS Number
Properties
Product Information
Application(s)
Antiinflammatory
Shows anti-HIV activity
Antispasmodic
Antitussive agent
Antitumourigenic activity in mice reported
Biological Source
Occurs in many plants in Leguminosae, Resedaceae, Euphorbiaceae, Umbelliferae, Scrophulariaceae, Fabaceae, Asteraceae, Cistaceae, Passifloraceae, Yerbenaceae and Hepaticae.
First isol. in 1832 from Reseda luteola
Pharmacology Properties
Mechanism of Action
Lipid peroxidation inhibitor in rat liver microsomes
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• Nagarathnam, D. et al., J.O.C., 1991, 56, 4884, (synth)
• Chari, V.M. et al., Phytochemistry, 1977, 16, 1273, (nmr)
• Youssef, D. et al., Planta Med., 1995, 61, 570, (pmr, cmr)
• Voirin, B., Phytochemistry, 1983, 22, 2107, (uv)
• Nevskaya, E.M., Zh. Anal. Khim., 1972, 27, 1699, (use)
• Plant Flavonoids in Biology and Medicine, (eds. Cody, V. et al), A. R. Liss, N. Y., 1986, (biol, prop)
• Inouye, H. et al., Chem. Ber., 1969, 102, 3009, (synth)
• 1994, 87, 107, (Luteolin, pharmacol)
• Mansour, R.M.A. et al., Phytochemistry, 1983, 22, 2630, (derivs)
• Kingston, D.G.I., Tetrahedron, 1971, 27, 2691, (ms)
• Markham, K.R. et al., J. Nat. Prod., 1987, 50, 660, (derivs)
• Diller, E., Ber., 1901, 34, 1452, (isol)
• Ono, K., Eur. J. Biochem., 1990, 190, 469, (anti-HIV activity)
• Dhar, K.L. et al., Planta Med., 1970, 18, 337, (isol, deriv)
• Wagner, H. et al., Tet. Lett., 1976, 1799, (nmr)
• Thieme, H., Tet. Lett., 1968, 2781, (derivs)
• Bandyukova, V.A., Khim. Prir. Soedin., 1969, 5, 595
• El-Ansari, M.A. et al., Phytochemistry, 1991, 30, 1169, (derivs)
• Perkin, A.G., J.C.S., 1900, 77, 1315, (isol)
• Litkei, G. et al., Annalen, 1995, 1711, (synth)
• Tomas, F. et al., Z. Naturforsch., C, 1985, 40, 583
• Karrer, W. et al., Konstitution und Vorkommen der Organischen Pflanzenstoffe, 2nd edn., Birkhuser Verlag, Basel, 1972, nos. 1470; 1473, (occur)
• Cody, V. et al., Plant Flavonoids in Biology and Medicine II, (eds., Cody, V. et al), A.R. Liss, N.Y., 1988, (biol, prop)