Substance
ID:449549
Names and Identifiers
Synonyms
RifaxidinRifacolNormixRifaximin
IUPAC name
(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,36-tetrahydroxy-11-methoxy-3,7,12,14,16,18,22,30-octamethyl-6,23-dioxo-8,37-dioxa-24,27,33-triazahexacyclo[23.10.1.14,7.05,35.026,34.027,32]heptatriaconta-1,3,5(35),9,19,21,25(36),26(34),28,30,32-undecaen-13-yl acetate
IUPAC Traditional name
(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,36-tetrahydroxy-11-methoxy-3,7,12,14,16,18,22,30-octamethyl-6,23-dioxo-8,37-dioxa-24,27,33-triazahexacyclo[23.10.1.14,7.05,35.026,34.027,32]heptatriaconta-1,3,5(35),9,19,21,25(36),26(34),28,30,32-undecaen-13-yl acetate
Registration numbers
CAS Number
Properties
Product Information
Application(s)
Antibacterial agent
Antibiotic
Pharmacology Properties
Mechanism of Action
Inhibits bacterial RNA synthesis by binding to bacterial DNA-dependent RNA polymerase
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• de Angelis, L., Drugs of the Future, 1982, 7, 260, (rev)
• Gillis, J.C. et al., Drugs, 1995, 49, 467, (rev)
• Marchi, E. et al., J. Med. Chem., 1985, 28, 960, (synth, pharmacol)
• Brufani, M. et al., J. Antibiot., 1984, 37, 1611, (synth, pmr, pharmacol)
• Venturini, A.P. et al., Chemioterapia, 1986, 5, 257; 263, (pharmacol, tox)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 200