Substance
ID:449535
Names and Identifiers
IUPAC name
7-(1,3-dioxolan-2-ylmethyl)-1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
Synonyms
AnsimarMaxiventDoxofylline
IUPAC Traditional name
7-(1,3-dioxolan-2-ylmethyl)-1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
Registration numbers
CAS Number
Properties
Product Information
Application(s)
Antitussive agent used for treatment of bronchospasm
Pharmacology Properties
Mechanism of Action
Increase in cyclic AMP inhibits activation of inflammatory cells in addition to bronchodilation
The bronchodilatory effect is due to their ability to inhibit phosphodiesterase (PDE) and thus inhibit breakdown of cAMP (cyclic adenosine monophosphate)
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• Bologna, E. et al., J. Int. Med. Res., 1990, 18, 282, (pharmacokinet)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, TEQ175
• U.K. Pat., 1978, Instituto Biologico Chemioterapico ABC, 1 582 510; CA, 90, 197858y, (pharmacol)
• Franzone, J.S. et al., Farmaco, Ed. Sci., 1981, 36, 220, (metab)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 1317
• Badini, C. et al., Farmaco, Ed. Sci., 1982, 37, 320, (hplc)