Substance
ID:449478
Names and Identifiers
IUPAC name
1-[(2-chlorophenyl)diphenylmethyl]-1H-imidazole
Synonyms
Clotrimazole
IUPAC Traditional name
1-[(2-chlorophenyl)diphenylmethyl]-1H-imidazole
Registration numbers
CAS Number
Properties
Product Information
Application(s)
Antifungal agent
Pharmacology Properties
Mechanism of Action
Induces membrane disruption
Appears to increase permeability of fungal-cell-membrane causing leakage of intracellular components.
Induces K+ release from Trichophyton mentagrophytes mycelium
Potent cytochrome P-450b and P-450c inhibitor
Functions as Lanosterol C-14 demethylation inhibitor
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• Song, H. et al., Acta Cryst. C, 1998, 54, 1675-1677, (cryst struct)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, MRX500
• Kracmar, J. et al., Cesk. Farm., 1977, 26, 345, (uv)
• Raab, W., Curr. Ther. Res., Clin. Exp., 1977, 22, 65, (pharmacol)
• Lewis, D.F.V. et al., J. Biochem. Toxicol., 1989, 4, 231, (pharmacol)
• Hoogerheide, J.G. et al., Anal. Profiles Drug Subst., 1982, 11, 225, (rev)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 7th edn., Akademie-Verlag, 1994, 8792
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 320
• Ruppert, J.F., Diss. Abstr. Int., B, 1977, 38, 2681, (synth)
• Buechel, K.H. et al., Arzneim.-Forsch., 1972, 22, 1260, (synth, pharmacol)