Substance
ID:449449
Names and Identifiers
Synonyms
TriclabendazoleFasinex
IUPAC name
5-chloro-6-(2,3-dichlorophenoxy)-2-(methylsulfanyl)-1H-1,3-benzodiazole
IUPAC Traditional name
5-chloro-6-(2,3-dichlorophenoxy)-2-(methylsulfanyl)-1H-1,3-benzodiazole
Registration numbers
CAS Number
Properties
Product Information
Application(s)
Anthelmintic (with active sulfoxide metabolite)
Description
Tautomers (~1:1)
Pharmacology Properties
Mechanism of Action
Binds to beta-tubulin and prevent the polymerisation of the microtubules of which they are part
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• Negro, A. et al., J. Chromatogr., 1992, 576, 135, (hplc)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 55
• Ger. Pat., 1978, Ciba-Geigy, 2 815 621; CA, 90, 38919c, (synth, pharmacol)
• Martin, P.A. et al., Vet. Rec., 1993, 133, 300, (tox)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, CFL200
• Stitt, A.W. et al., Parasitol. Res., 1993, 79, 529, (pharmacol)