Substance
ID:449426
Names and Identifiers
IUPAC name
5,5-diphenylimidazolidine-2,4-dione
Synonyms
PhenytoinEpsolinFenitoinPhenhydanPyoredolDi-HydanEpanutinFenytoinePhenantoinFenantoinPentranZentropilAleviatin
IUPAC Traditional name
5,5-diphenylimidazolidine-2,4-dione
Registration numbers
CAS Number
Properties
Pharmacology Properties
Mechanism of Action
Reduces posttetanic potentiation at synapses preventing cortical seizure foci from detonating adjacent cortical areas
May promote neuronal sodium-efflux so stabilizing threshold against hyperexcitability caused by events capable of reducing membrane sodium gradient
Apparent motor cortex depressant
Apparent primary site of action is motor-cortex where spread of seizure activity is inhibited
Reduces the maximal activity of brain-stem centers responsible for the tonic-phase of grand-mal seizures
Product Information
Application(s)
Anticonvulsant
Antiepileptic (veterinary product)
Molecule Details
No Data Available
Click here to submit data
Molecular Spectra
No Data Available
Click here to submit data
References
• Aldrich Library of FT-IR Spectra, 1st edn., 1985, 2, 398C, (ir)
• Camerman, A. et al., Acta Cryst. B, 1971, 27, 2205, (cryst struct)
• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 2, 1446C, (nmr)
• Woodbury, D.M., Adv. Neurol., 1980, 27, 447, (rev)
• Long, R.C. et al., J. Magn. Reson., 1974, 16, 228, (nmr)
• Glazko, A.J., Ther. Drug Monit., 1986, 8, 490, (rev)
• IARC Monog., 1977, 13, 201; Suppl. 7, 319; Suppl. 6, 463, (rev, tox)
• Antiepileptic Drugs, (Eds., Levy, R.H. et al), 4th edn., Raven Press, 1995, 301, (rev)
• Jones, G.L. et al., Handb. Exp. Pharmacol., 1985, 74, 351, (rev, pharmacol)
• Simig, G. et al., Tetrahedron, 1975, 31, 1195, (synth)
• Goenechea, S., Mikrochim. Acta, 1972, 276, (ir)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 7th edn., Akademie-Verlag, 1994, 4403, (synonyms)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, DKQ000; DNU000
• Gillis, R.A. et al., J. Pharmacol. Exp. Ther., 1971, 179, 599, (pharmacol)
• Ruecker, G. et al., Arch. Pharm. (Weinheim, Ger.), 1971, 304, 883, (ms)
• Philip, J. et al., Anal. Profiles Drug Subst., 1984, 13, 417, (rev)
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 352