Substance
ID:449426
Names and Identifiers
IUPAC name
5,5-diphenylimidazolidine-2,4-dione
Synonyms
PhenytoinEpsolinFenitoinPhenhydanPyoredolDi-HydanEpanutinFenytoinePhenantoinFenantoinPentranZentropilAleviatin
IUPAC Traditional name
5,5-diphenylimidazolidine-2,4-dione
Registration numbers
CAS Number
Properties
Pharmacology Properties
Mechanism of Action
Apparent primary site of action is motor-cortex where spread of seizure activity is inhibited
Reduces the maximal activity of brain-stem centers responsible for the tonic-phase of grand-mal seizures
May promote neuronal sodium-efflux so stabilizing threshold against hyperexcitability caused by events capable of reducing membrane sodium gradient
Apparent motor cortex depressant
Reduces posttetanic potentiation at synapses preventing cortical seizure foci from detonating adjacent cortical areas
Product Information
Application(s)
Anticonvulsant
Antiepileptic (veterinary product)
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• Aldrich Library of FT-IR Spectra, 1st edn., 1985, 2, 398C, (ir)
• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 2, 1446C, (nmr)
• Goenechea, S., Mikrochim. Acta, 1972, 276, (ir)
• Long, R.C. et al., J. Magn. Reson., 1974, 16, 228, (nmr)
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 352
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, DKQ000; DNU000
• Camerman, A. et al., Acta Cryst. B, 1971, 27, 2205, (cryst struct)
• Simig, G. et al., Tetrahedron, 1975, 31, 1195, (synth)
• Woodbury, D.M., Adv. Neurol., 1980, 27, 447, (rev)
• Jones, G.L. et al., Handb. Exp. Pharmacol., 1985, 74, 351, (rev, pharmacol)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 7th edn., Akademie-Verlag, 1994, 4403, (synonyms)
• Ruecker, G. et al., Arch. Pharm. (Weinheim, Ger.), 1971, 304, 883, (ms)
• Philip, J. et al., Anal. Profiles Drug Subst., 1984, 13, 417, (rev)
• Gillis, R.A. et al., J. Pharmacol. Exp. Ther., 1971, 179, 599, (pharmacol)
• IARC Monog., 1977, 13, 201; Suppl. 7, 319; Suppl. 6, 463, (rev, tox)
• Antiepileptic Drugs, (Eds., Levy, R.H. et al), 4th edn., Raven Press, 1995, 301, (rev)
• Glazko, A.J., Ther. Drug Monit., 1986, 8, 490, (rev)