Substance
ID:4494
Names and Identifiers
Synonyms
ChloroiodoquineCaswell No. 193Clioquinolum [inn-latin]IodochloroxineIodochlorohydroxyquinIodochlorhydroxyquinIODOIodochlorhydroxyquinolineIodochlorhydroxyquinolChloroiodoquinChloro-8-hydroxyiodoquinolineIodoxyquinolineJodchloroxychinolinum5-Chloro-7-iodo-8-hydroxyquinoline7-Iodo-5-chloro-8-hydroxyquinoline7-Iodo-5-chloroxineCliochinolo [dcit]IodochloroquineIodochlorohydroxyquinolineClioquinol5-Chlor-7-jod-8-hydroxy-chinolin [German]5-Chloro-7-iodo-8-quinolinol5-Chloro-7-iodoquinolin-8-ol5-Chloro-8-hydroxy-7-iodoquinolineIodochloroxyquinolineIodochloroxychinolinum
Brand Name
IodenterolLoquinolOralcerQuinambicideQuinoformVioformioEntero-septolEntero-vioformEnteroquinolEnterum locortenFormtone-HCHydriodide-enterolAmebilBarquinolCifoformCort-quinCremo-quinEntero-bioformAla-quinAlioformNioformNystaformQuin-o-cremeEmaformEntero-vioformioEnterovalodonHysoneLekoseptLidaform-HCCliquinolCortinDomeformEczecidinVioform-hydrocortisoneEnterozolEntrokinHi-enterolMycoquinRheaformVioformChinoformChinoformumChlorojodochinCliochinolumCorqueDioquinolAlchloquinBactolBudoformEnterseptolHi-eneterolIodoenterolRacetRometinUad lotionAmoenolDermaformDomeform-HCEnteritanEntero-bio formEnteroseptol
IUPAC Traditional name
clioquinol
IUPAC name
5-chloro-7-iodoquinolin-8-ol
Properties
No Data Available
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Molecule Details
Drug Groups
withdrawn
Description
Clioquinol was withdrawn in 1983 due to neurotoxicity.
Indication
Used as a topical antifungal treatment.
Pharmacology
Clioquinol is a broad-spectrum antibacterial with antifungal properties. Application of clioquinol to extensive or eroded areas of the skin may lead to increased protein-bound iodine (PBI) levels within 1 week. In addition, elevated PBI levels may occur when relatively small areas of the skin are treated with clioquinol for more than 1 week.
Absorption
Topical absorption is rapid and extensive, especially when the skin is covered with an occlusive dressing or if the medication is applied to extensive or eroded areas of the skin. Clioquinol is absorbed through the skin in sufficient amounts to affect thyroid function tests.
References
•
Rohde W, Mikelens P, Jackson J, Blackman J, Whitcher J, Levinson W: Hydroxyquinolines inhibit ribonucleic acid-dependent deoxyribonucleic acid polymerase and inactivate Rous sarcoma virus and herpes simplex virus. Antimicrob Agents Chemother. 1976 Aug;10(2):234-40.
[Pubmed]
•
GHOLZ LM, ARONS WL: PROPHYLAXIS AND THERAPY OF AMEBIASIS AND SHIGELLOSIS WITH IODOCHLORHYDROXYQUIN. Am J Trop Med Hyg. 1964 May;13:396-401.
[Pubmed]
•
Kager PA: [Outbreak of amoebiasis in a Dutch family; tropics unexpectedly nearby] Ned Tijdschr Geneeskd. 2005 Jan 1;149(1):51-2; author reply 52-3.
[Pubmed]
•
Bosman DK, Benninga MA, van de Berg P, Kooijman GC, van Gool T: [Dientamoeba fragilis: possibly an important cause of persistent abdominal pain in children] Ned Tijdschr Geneeskd. 2004 Mar 20;148(12):575-9.
[Pubmed]
•
Masters DK, Hopkins AD: Therapeutic trial of four amoebicide regimes in rural Zaire. J Trop Med Hyg. 1979 May;82(5):99-101.
[Pubmed]
External Links
Molecular Spectra
No Data Available
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References
• Rohde W, Mikelens P, Jackson J, Blackman J, Whitcher J, Levinson W: Hydroxyquinolines inhibit ribonucleic acid-dependent deoxyribonucleic acid polymerase and inactivate Rous sarcoma virus and herpes simplex virus. Antimicrob Agents Chemother. 1976 Aug;10(2):234-40. Pubmed
• Kager PA: [Outbreak of amoebiasis in a Dutch family; tropics unexpectedly nearby] Ned Tijdschr Geneeskd. 2005 Jan 1;149(1):51-2; author reply 52-3. Pubmed
• GHOLZ LM, ARONS WL: PROPHYLAXIS AND THERAPY OF AMEBIASIS AND SHIGELLOSIS WITH IODOCHLORHYDROXYQUIN. Am J Trop Med Hyg. 1964 May;13:396-401. Pubmed
• Bosman DK, Benninga MA, van de Berg P, Kooijman GC, van Gool T: [Dientamoeba fragilis: possibly an important cause of persistent abdominal pain in children] Ned Tijdschr Geneeskd. 2004 Mar 20;148(12):575-9. Pubmed
• Masters DK, Hopkins AD: Therapeutic trial of four amoebicide regimes in rural Zaire. J Trop Med Hyg. 1979 May;82(5):99-101. Pubmed