Substance
ID:449337
Names and Identifiers
IUPAC name
2-hydroxy-1,4-dihydronaphthalene-1,4-dione
Synonyms
Natural Orange 6LawsoneHenna
IUPAC Traditional name
2-hydroxy-1,4-dihydronaphthalene-1,4-dione
Registration numbers
CAS Number
Properties
Product Information
Application(s)
Possesses antiinflammatory, analgesic and antipyretic activity
Antispasmodic agent, fungicide, bactericide and ingredient of sunscreen preparations
Antineoplastic
Biological Source
Isol. from Lawsonia spp., henna and seeds of Lomatia ferruginea.
Also from Impatiens spp.
Pharmacology Properties
Mechanism of Action
Inhibitor of NADPH-cytochrome C reductase
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• Martindale, The Extra Pharmacopoeia, 31st edn., Pharmaceutical Press, 1996, 1719
• Dekkers, J. et al., Acta Cryst. C, 1996, 52, 2896-2899, (cryst struct)
• Fieser, L.F., J.A.C.S., 1948, 70, 3165, (synth)
• Amorosa, M., Gazz. Chim. Ital., 1954, 84, 602, (synth)
• Aldrich Library of FT-IR Spectra, 1st edn., 1985, 2, 79D, (ir)
• Baillie, A.C. et al., J.C.S.(C), 1966, 2185, (synth)
• Zinkham, W.H. et al., Pediatrics, 1996, 7, 707, (tox)
• Ishiguro, K. et al., J. Nat. Prod., 1998, 61, 1126-1129, (deriv, isol, pmr, cmr)
• Japan. Pat., 1971, Mitsubishi Edogawa, 71 02 978; CA, 75, 48769h, (synth)
• Chapelle, J.P., Phytochemistry, 1974, 13, 662, (isol, deriv)
• Org. Synth., Coll. Vol., 3, 1955, 465
• Chen, D. et al., Can. J. Biochem., 1966, 44, 1389, (biosynth)
• Fieser and Fieser's Reagents for Organic Synthesis, Wiley, 1967, 1, 484
• Yano, H. et al., Chem. Pharm. Bull., 1980, 28, 1207, (cmr)
• Munday, R. et al., J. Appl. Toxicol., 1991, 11, 85, (tox)
• Ali, B.H. et al., Pharmacology, 1995, 51, 356, (pharmacol)
• Japan. Pat., 1971, Mitsubishi Edogawa, 71 02 977; CA, 74, 141384, (synth)
• Aldrich Library of NMR Spectra, 2nd edn., 1983, 2, 86A, (nmr)
• Mehendale, A.R. et al., Phytochemistry, 1975, 14, 801, (isol)