Substance
ID:449259
Names and Identifiers
IUPAC name
5-chloro-N-[2-(4-{[(cyclohexylcarbamoyl)amino]sulfonyl}phenyl)ethyl]-2-methoxybenzamide
Synonyms
MicronaseGlynaseGlyburideSemi-DaonilGlibenclamideEugluconGilemalDaonilDiaBetaDiabetamideMalixLibanilCalabren
IUPAC Traditional name
5-chloro-N-[2-(4-{[(cyclohexylcarbamoyl)amino]sulfonyl}phenyl)ethyl]-2-methoxybenzamide
Registration numbers
CAS Number
Properties
Product Information
Application(s)
Antidiabetic drug (type II diabetes)
Inhibits drug-induced coronary vasodilation
Pharmacology Properties
Mechanism of Action
ATP-sensitive potassium channels (KATP) blocker in pancreatic beta cells
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• Aumller, W. et al., Arzneim.-Forsch., 1966, 16, 1640, (synth)
• Takla, P.G., Anal. Profiles Drug Subst., 1981, 10, 337, (rev)
• Katsuda, Y. et al., Circulation, 1995, 92, 511, (pharmacol)
• Prendergast, B.D., Clin. Pharm., 1984, 3, 473, (rev, pharmacol)
• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 2, 1639B, (nmr)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 6870, (synonyms)
• Am. J. Med., Suppl., 1990, 89, 2A, (rev)
• Weber, H. et al., Arzneim.-Forsch., 1969, 19, 1323, (numerous papers)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, CEH700
• Krall, L.P. et al., Clin. Ther., 1984, 6, 746, (rev, pharmacol)
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 319