Substance
ID:449239
Names and Identifiers
IUPAC name
(2S)-2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}phenyl)formamido]pentanedioic acid
Synonyms
MexateMethylaminopterinAmethopterinMethotrexateExtexateMaxtrex
IUPAC Traditional name
(2S)-2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}phenyl)formamido]pentanedioic acid
Registration numbers
CAS Number
Properties
Pharmacology Properties
Mechanism of Action
Dihydrofolate reductase inhibitor
Product Information
Application(s)
Used in the treatment of rheumatoid arthritis.
Antineoplastic and antipsoriatic agent
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• Piper, J.R. et al., J. Het. Chem., 1974, 11, 279, (synth)
• Piper, J.R. et al., J. Med. Chem., 1982, 25, 182-187; 1983, 26, 291-294, (homologues)
• Bannwarth, B. et al., Drugs, 1994, 47, 25, (use, rev)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 9th edn., Van Nostrand Reinhold, 1996, MDV500; MDV600
• Faupel, P. et al., Angew. Chem., Int. Ed., 1988, 27, 423, (uv, cd, conformn)
• Seeger, D.R. et al., J.A.C.S., 1949, 71, 1753, (synth, uv)
• Pastore, E.J., Ann. N.Y. Acad. Sci., 1971, 186, 43, (pmr)
• Suster, D.C. et al., Rev. Roum. Chim., 1977, 22, 1195-1207, (synth, uv)
• Hambley, T.W. et al., J.A.C.S., 1986, 108, 2103, (cryst struct)
• Mathers, D. et al., Inflammatory Dis. Ther., 1992, 9, 287, (rev)
• Albertioni, F. et al., Clin. Chem. (Winston-Salem, N.C.), 1996, 42, 39, (hplc, anal)
• Martindale, The Extra Pharmacopoeia, 31st edn., Pharmaceutical Press, 1996, 584
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 5672
• Rahman, L.K. et al., Med. Res. Rev., 1988, 8, 95, (rev, chem)
• Matherly, L.H. et al., Pharmacol. Ther., 1987, 35, 27, (rev, metab, pharmacol)
• Rosowsky, A. et al., Prog. Med. Chem., 1989, 26, 1, (sar, rev)
• IARC Monog., 1981, 26, 267; Suppl. 7, 241; Suppl. 6, 372, (rev, tox)
• Cheung, H.T. et al., Heterocycles, 1987, 25, 507, (synth)
• Wilke, W.S., Methotrexate Therapy in Rheumatic Disease, Marcel Dekker (Ed. Wilke, W.S.), 1989, (book)
• Chamberlain, A.R. et al., Anal. Profiles Drug Subst., 1976, 5, 283, (anal)
• Kimura, K. et al., Prog. Cancer Res. Ther., 1986, 33, (book)
• DeGraw, J.I. et al., J. Labelled Compd. Radiopharm., 1989, 27, 112, (synth, labelled compd)