Substance
ID:449223
Names and Identifiers
IUPAC name
1,3-bis(2-chloroethyl)-1-nitrosourea
IUPAC Traditional name
1,3-bis(2-chloroethyl)-1-nitrosourea
Synonyms
CarmustineBecenumCarmubrisNitrumon
Registration numbers
CAS Number
Properties
Product Information
Application(s)
Used to treat gliomas, glioblastoma multiforme, medulloblastoma and astrocytoma, multiple myeloma and lymphoma (Hodgkin's and non-Hodgkin).
Antineoplastic agent
Pharmacology Properties
Mechanism of Action
Alkylating agent in cancer chemotherapy
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• Lown, J.W. et al., J.O.C., 1981, 46, 5309, (synth, cmr, N-15 nmr)
• Paoletti, R. et al., Am. J. Cardiol., 1983, 52, 21, (rev)
• Johnston, T.P. et al., J. Med. Chem., 1963, 6, 669, (synth)
• Lien, E.J. et al., Spectrosc. Lett., 1972, 5, 293, (pmr)
• Thompson, G.R. et al., Toxicol. Appl. Pharmacol., 1972, 21, 405, (tox)
• IARC Monog., 1981, 26, 79; Suppl. 6, 116; Suppl. 7, 150, (rev, tox)
• Wiencke, J.K. et al., Mutat. Res., 1995, 339, 91, (rev, genotox)
• Martindale, The Extra Pharmacopoeia, 31st edn., Pharmaceutical Press, 1996, 550
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, BIF750
• Gombar, C.T. et al., Diss. Abstr. Int., B, 1980, 40, 5223; 5686, (props)
• Kaba, S.E. et al., Drugs, 1997, 53, 235, (use, rev)
• Loo, T.L. et al., J. Pharm. Sci., 1966, 55, 492, (pharmacol)
• Reed, D.J. et al., Anticancer Drugs: Reactive Metabolism and Drug Interactions, (Ed. Powis, G.) Pergamon Press, 1994, 187, (rev)