Substance
ID:449204
Names and Identifiers
IUPAC name
2-hydroxypropane-1,2,3-tricarboxylic acid; 5-{2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-3-propyl-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one
Synonyms
RevatioViagraSildenafil Citrate
IUPAC Traditional name
2-hydroxypropane-1,2,3-tricarboxylic acid; 5-{2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-3-propyl-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one
Registration numbers
CAS Number
Properties
Product Information
Application(s)
Used to treat male erectile dysfunction (impotence) and pulmonary arterial hypertension (PAH)
Salt Data
Citrate
Pharmacology Properties
Mechanism of Action
Vasodilator
Selective inhibitor of cyclic GMP specific phosphodiesterase (Type V)
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• Palmer, E., Chem. Br., 1999, 24-26, (rev)
• Martel, A.M. et al., Drugs of the Future, 1997, 22, 138-143, (synth, pharmacol)
• Morales, A. et al., Int. J. Impot. Res., 1998, 10, 69-74, (use)
• Ballard, S.A. et al., J. Urol. (Baltimore), 1998, 159, 2164-2171; 160, 242-246, (pharmacol)
• Langtry, H.D. et al., Drugs, 1999, 57, 967-989
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 1629
• Terrett, N.K. et al., Bioorg. Med. Chem. Lett., 1996, 6, 1819-1824, (sildenafil citrate)
• Chuang, A.T. et al., J. Urol. (Baltimore), 1998, 160, 257-261, (pharmacol)
• Dale, D.J. et al., Org. Process Res. Dev., 2000, 4, 17-22, (synth)
• Eur. Pat., 1992, Pfizer, 463 756; CA, 116, 255626q, (synth, pharmacol)
• Cheitlin, M.D. et al., Circulation, 1999, 99, 168-177
• Boolell, M. et al., Br. J. Urol., 1996, 78, 257-261, (pharmacol)
• Cooper, J.D.H. et al., J. Chromatogr., B: Biomed. Appl., 1997, 701, 87-95, (hplc)
• Noss, M.B. et al., Drugs of Today (Barcelona), 1999, 35, 211-217